3-[5-(2-trifluoromethoxyphenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride

Base Information

Chemical Name:3-[5-(2-trifluoromethoxyphenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride
CAS No.:1259026-98-6
Molecular Formula:C₂₃H₁₉F₆N₃O₂*ClH
Molecular Weight:519.874
Hs Code.:

Synonyms:3-[5-(2-trifluoromethoxyphenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride

Suppliers and Price of 3-[5-(2-trifluoromethoxyphenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[5-(2-trifluoromethoxyphenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[5-(2-trifluoromethoxyphenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride

There total 8 articles about 3-[5-(2-trifluoromethoxyphenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1221349-77-4
3-[5-(2-trifluoromethoxyphenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

: 1259026-98-6
3-[5-(2-trifluoromethoxyphenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; ethyl acetate;
DOI:10.1021/jm101075v

Reference yield:

: 1015770-74-7
1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid ethyl ester

: 1259026-98-6
3-[5-(2-trifluoromethoxyphenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydrochloride monohydrate; water / methanol / 16 h / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

3.1: triethylamine / dichloromethane / 2 h / 20 °C

3.2: 3 h / 100 °C

4.1: hydrogenchloride / diethyl ether; ethyl acetate

With hydrogenchloride; oxalyl dichloride; lithium hydrochloride monohydrate; water; triethylamine; N,N-dimethyl-formamide; In methanol; diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1021/jm101075v

Reference yield:

: 1259026-63-5
3-nitro-2'-(trifluoromethoxy)-5-(trifluoromethyl)-[1,1'-biphenyl]-4-amine

: 1259026-98-6
3-[5-(2-trifluoromethoxyphenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; iron / ethanol; water / 4 h / 80 °C

2.1: triethylamine / dichloromethane / 2 h / 20 °C

2.2: 3 h / 100 °C

3.1: hydrogenchloride / diethyl ether; ethyl acetate

With hydrogenchloride; iron; triethylamine; In diethyl ether; ethanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/jm101075v