3-[5-(2-trifluoromethoxyphenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

Base Information

• Chemical Name: 3-[5-(2-trifluoromethoxyphenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene
• CAS No.: 1221349-77-4
• Molecular Formula: C₂₃H₁₉F₆N₃O₂
• Molecular Weight: 483.413
• Mol file: 1221349-77-4.mol

Synonyms:3-[5-(2-trifluoromethoxyphenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

Chemical Property of 3-[5-(2-trifluoromethoxyphenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[5-(2-trifluoromethoxyphenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

There total 7 articles about 3-[5-(2-trifluoromethoxyphenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid chloride (1259026-33-9) + C14H10F6N2O → 3-[5-(2-trifluoromethoxyphenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene (1221349-77-4)

Guidance literature:

1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid chloride; C₁₄H₁₀F₆N₂O; With triethylamine; In dichloromethane; at 20 ℃; for 2h;

With camphor-10-sulfonic acid; In 1,4-dioxane; at 100 ℃; for 3h;

DOI:10.1021/jm101075v

Reference yield:

1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid ethyl ester (1015770-74-7) → 3-[5-(2-trifluoromethoxyphenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene (1221349-77-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium hydrochloride monohydrate; water / methanol / 16 h / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

3.1: triethylamine / dichloromethane / 2 h / 20 °C

3.2: 3 h / 100 °C

With oxalyl dichloride; lithium hydrochloride monohydrate; water; triethylamine; N,N-dimethyl-formamide; In methanol; dichloromethane;

DOI:10.1021/jm101075v

Reference yield:

3-nitro-2'-(trifluoromethoxy)-5-(trifluoromethyl)-[1,1'-biphenyl]-4-amine (1259026-63-5) → 3-[5-(2-trifluoromethoxyphenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene (1221349-77-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; iron / ethanol; water / 4 h / 80 °C

2.1: triethylamine / dichloromethane / 2 h / 20 °C

2.2: 3 h / 100 °C

With hydrogenchloride; iron; triethylamine; In ethanol; dichloromethane; water;

DOI:10.1021/jm101075v

upstream raw materials:

1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid ethyl ester

1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid chloride

3-nitro-2'-(trifluoromethoxy)-5-(trifluoromethyl)-[1,1'-biphenyl]-4-amine

1-oxa-2-azaspiro[4.5]dec-2-ene-3-carboxylic acid

Downstream raw materials:

3-[5-(2-trifluoromethoxyphenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride