3-(2,4-dimethyl-thiazol-5-yl)-5-(4-methoxy-benzylsulfanyl)-4-naphthalen-2-yl-4H-[1,2,4]triazole

Base Information

Chemical Name:3-(2,4-dimethyl-thiazol-5-yl)-5-(4-methoxy-benzylsulfanyl)-4-naphthalen-2-yl-4H-[1,2,4]triazole
CAS No.:318467-46-8
Molecular Formula:C₂₅H₂₂N₄OS₂
Molecular Weight:458.608
Hs Code.:

3-(2,4-dimethyl-thiazol-5-yl)-5-(4-methoxy-benzylsulfanyl)-4-naphthalen-2-yl-4<i>H</i>-[1,2,4]triazole

Synonyms:3-(2,4-dimethyl-thiazol-5-yl)-5-(4-methoxy-benzylsulfanyl)-4-naphthalen-2-yl-4H-[1,2,4]triazole

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Chemical Property of 3-(2,4-dimethyl-thiazol-5-yl)-5-(4-methoxy-benzylsulfanyl)-4-naphthalen-2-yl-4H-[1,2,4]triazole

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Technology Process of 3-(2,4-dimethyl-thiazol-5-yl)-5-(4-methoxy-benzylsulfanyl)-4-naphthalen-2-yl-4H-[1,2,4]triazole

There total 4 articles about 3-(2,4-dimethyl-thiazol-5-yl)-5-(4-methoxy-benzylsulfanyl)-4-naphthalen-2-yl-4H-[1,2,4]triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 824-94-2
p-methoxybenzyl chloride

: 318467-35-5
5-(2,4-dimethyl-thiazol-5-yl)-4-naphthalen-2-yl-2,4-dihydro-[1,2,4]triazole-3-thione

: 318467-46-8
3-(2,4-dimethyl-thiazol-5-yl)-5-(4-methoxy-benzylsulfanyl)-4-naphthalen-2-yl-4H-[1,2,4]triazole

Guidance literature:: 5-(2,4-dimethyl-thiazol-5-yl)-4-naphthalen-2-yl-2,4-dihydro-[1,2,4]triazole-3-thione; With potassium hydroxide; In ethanol; for 0.5h;

p-methoxybenzyl chloride; In ethanol; at 20 ℃; for 4h;
DOI:10.1002/1521-4184(200010)333:10<347::AID-ARDP347>3.0.CO;2-6

Reference yield:

: 99357-25-2
2,4-dimethyl-thiazole-5-carboxylic acid hydrazide

: 318467-46-8
3-(2,4-dimethyl-thiazol-5-yl)-5-(4-methoxy-benzylsulfanyl)-4-naphthalen-2-yl-4H-[1,2,4]triazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 76 percent / aq. NaOH / ethanol / 3 h

2.1: 71 percent / NaHCO₃ / H₂O / 12 h / 120 - 140 °C

3.1: KOH / ethanol / 0.5 h

3.2: 86 percent / ethanol / 4 h / 20 °C

With potassium hydroxide; sodium hydroxide; sodium hydrogencarbonate; In ethanol; water;
DOI:10.1002/1521-4184(200010)333:10<347::AID-ARDP347>3.0.CO;2-6

Reference yield:

: 1636-33-5
2-naphthyl isothiocyanate

: 318467-46-8
3-(2,4-dimethyl-thiazol-5-yl)-5-(4-methoxy-benzylsulfanyl)-4-naphthalen-2-yl-4H-[1,2,4]triazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 76 percent / aq. NaOH / ethanol / 3 h

2.1: 71 percent / NaHCO₃ / H₂O / 12 h / 120 - 140 °C

3.1: KOH / ethanol / 0.5 h

3.2: 86 percent / ethanol / 4 h / 20 °C

With potassium hydroxide; sodium hydroxide; sodium hydrogencarbonate; In ethanol; water;
DOI:10.1002/1521-4184(200010)333:10<347::AID-ARDP347>3.0.CO;2-6