cyclobutyl[9-(4-fluorobenzyl)-7,7a,8,9,10,11-hexahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepin-5(6H)-yl]methanone

Base Information

Chemical Name:cyclobutyl[9-(4-fluorobenzyl)-7,7a,8,9,10,11-hexahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepin-5(6H)-yl]methanone
CAS No.:1350460-12-6
Molecular Formula:C₂₃H₂₇FN₄O
Molecular Weight:394.492
Hs Code.:

Synonyms:cyclobutyl[9-(4-fluorobenzyl)-7,7a,8,9,10,11-hexahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepin-5(6H)-yl]methanone

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Chemical Property of cyclobutyl[9-(4-fluorobenzyl)-7,7a,8,9,10,11-hexahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepin-5(6H)-yl]methanone

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Technology Process of cyclobutyl[9-(4-fluorobenzyl)-7,7a,8,9,10,11-hexahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepin-5(6H)-yl]methanone

There total 8 articles about cyclobutyl[9-(4-fluorobenzyl)-7,7a,8,9,10,11-hexahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepin-5(6H)-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350460-11-5
9-(4-fluorobenzyl)-5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine

: 5006-22-4
Cyclobutanecarbonyl chloride

: 1350460-12-6
cyclobutyl[9-(4-fluorobenzyl)-7,7a,8,9,10,11-hexahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepin-5(6H)-yl]methanone

Guidance literature:: 9-(4-fluorobenzyl)-5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine; Cyclobutanecarbonyl chloride; In dichloromethane; at 20 ℃; for 12h;

With sodium carbonate; In dichloromethane; for 0.5h;

With sodium hydroxide; In dichloromethane; pH=~ 9;

Reference yield:

: 183742-32-7
1,4-dibenzyl-2-methoxycarbonylmethylpiperazine

: 1350460-12-6
cyclobutyl[9-(4-fluorobenzyl)-7,7a,8,9,10,11-hexahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepin-5(6H)-yl]methanone

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride; hydrogen / 20% palladium hydroxide-activated charcoal / water; methanol / 22 h / 20 °C / 1551.49 Torr

2.1: potassium carbonate / ethyl acetate; water / 22 h / 20 °C / 1551.49 Torr

2.2: 3.08 h / 20 °C / Cooling with ice

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 7 h / 95 °C / Inert atmosphere

4.1: hydrogen / platinum(IV) oxide / methanol / 54 h / 760.05 Torr

4.2: 41 h / Reflux

5.1: dichloromethane / 1.85 h / 0 - 20 °C

6.1: sodium hydroxide / dichloromethane

6.2: 13 h / 20 °C

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Reflux; Inert atmosphere

7.2: Inert atmosphere; Cooling with ice

8.1: dichloromethane / 12 h / 20 °C

8.2: 0.5 h

8.3: pH ~ 9

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; platinum(IV) oxide; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 183742-33-8,1217683-44-7
3-(methoxycarbonylmethyl)piperazine-1-carboxylic acid tert-butyl ester

: 1350460-12-6
cyclobutyl[9-(4-fluorobenzyl)-7,7a,8,9,10,11-hexahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepin-5(6H)-yl]methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 7 h / 95 °C / Inert atmosphere

2.1: hydrogen / platinum(IV) oxide / methanol / 54 h / 760.05 Torr

2.2: 41 h / Reflux

3.1: dichloromethane / 1.85 h / 0 - 20 °C

4.1: sodium hydroxide / dichloromethane

4.2: 13 h / 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Reflux; Inert atmosphere

5.2: Inert atmosphere; Cooling with ice

6.1: dichloromethane / 12 h / 20 °C

6.2: 0.5 h

6.3: pH ~ 9

With lithium aluminium tetrahydride; hydrogen; N-ethyl-N,N-diisopropylamine; sodium hydroxide; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;