9-(4-fluorobenzyl)-5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine

Base Information

Chemical Name:9-(4-fluorobenzyl)-5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine
CAS No.:1350460-11-5
Molecular Formula:C₁₈H₂₁FN₄
Molecular Weight:312.39
Hs Code.:

Synonyms:9-(4-fluorobenzyl)-5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine

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Chemical Property of 9-(4-fluorobenzyl)-5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine

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Technology Process of 9-(4-fluorobenzyl)-5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine

There total 7 articles about 9-(4-fluorobenzyl)-5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350460-10-4
9-(4-fluorobenzoyl)-7,7a,8,9,10,11-hexahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepin-6(5H)-one

: 1350460-11-5
9-(4-fluorobenzyl)-5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine

Guidance literature:: 9-(4-fluorobenzoyl)-7,7a,8,9,10,11-hexahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepin-6(5H)-one; With lithium aluminium tetrahydride; In tetrahydrofuran; for 1h; Reflux; Inert atmosphere;

With water; sodium hydroxide; In tetrahydrofuran; ethyl acetate; Inert atmosphere; Cooling with ice;

Reference yield:

: 183742-32-7
1,4-dibenzyl-2-methoxycarbonylmethylpiperazine

: 1350460-11-5
9-(4-fluorobenzyl)-5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride; hydrogen / 20% palladium hydroxide-activated charcoal / water; methanol / 22 h / 20 °C / 1551.49 Torr

2.1: potassium carbonate / ethyl acetate; water / 22 h / 20 °C / 1551.49 Torr

2.2: 3.08 h / 20 °C / Cooling with ice

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 7 h / 95 °C / Inert atmosphere

4.1: hydrogen / platinum(IV) oxide / methanol / 54 h / 760.05 Torr

4.2: 41 h / Reflux

5.1: dichloromethane / 1.85 h / 0 - 20 °C

6.1: sodium hydroxide / dichloromethane

6.2: 13 h / 20 °C

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Reflux; Inert atmosphere

7.2: Inert atmosphere; Cooling with ice

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; platinum(IV) oxide; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 183742-33-8,1217683-44-7
3-(methoxycarbonylmethyl)piperazine-1-carboxylic acid tert-butyl ester

: 1350460-11-5
9-(4-fluorobenzyl)-5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 7 h / 95 °C / Inert atmosphere

2.1: hydrogen / platinum(IV) oxide / methanol / 54 h / 760.05 Torr

2.2: 41 h / Reflux

3.1: dichloromethane / 1.85 h / 0 - 20 °C

4.1: sodium hydroxide / dichloromethane

4.2: 13 h / 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Reflux; Inert atmosphere

5.2: Inert atmosphere; Cooling with ice

With lithium aluminium tetrahydride; hydrogen; N-ethyl-N,N-diisopropylamine; sodium hydroxide; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;