Technology Process of 3-[3-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 2,3,5,6-tetrafluoropyridin-4-ylamide
There total 6 articles about 3-[3-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 2,3,5,6-tetrafluoropyridin-4-ylamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,3,5,6-tetrafluoropyridin-4-amine;
With
tert.-butyl lithium;
In
diethyl ether; hexane;
at -78 ℃;
C11H5ClF3NO2;
In
N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; hexane;
at -78 - 20 ℃;
DOI:10.1007/s00706-010-0265-9
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydroxylamine
2.1: N-chloro-succinimide / N,N-dimethyl-formamide
3.1: magnesium sulfate; triethylamine / toluene / 20 °C
4.1: N-Bromosuccinimide
5.1: water; sodium hydroxide / ethanol
6.1: oxalyl dichloride / benzene
7.1: tert.-butyl lithium / diethyl ether; hexane / -78 °C
7.2: -78 - 20 °C
With
N-chloro-succinimide; N-Bromosuccinimide; oxalyl dichloride; water; hydroxylamine; tert.-butyl lithium; magnesium sulfate; triethylamine; sodium hydroxide;
In
diethyl ether; ethanol; hexane; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1007/s00706-010-0265-9
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: oxalyl dichloride / benzene
2.1: tert.-butyl lithium / diethyl ether; hexane / -78 °C
2.2: -78 - 20 °C
With
oxalyl dichloride; tert.-butyl lithium;
In
diethyl ether; hexane; benzene;
DOI:10.1007/s00706-010-0265-9