(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(1-bromopropyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

Base Information

Chemical Name:(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(1-bromopropyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one
CAS No.:944158-28-5
Molecular Formula:C₂₃H₁₉BrF₉NO₂
Molecular Weight:592.299
Hs Code.:

Synonyms:(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(1-bromopropyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

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Chemical Property of (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(1-bromopropyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

Chemical Property:

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Technology Process of (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(1-bromopropyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

There total 11 articles about (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(1-bromopropyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 944158-29-6
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(1-hydroxypropyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

: 944158-28-5
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(1-bromopropyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 72h;

Reference yield:

: 875446-35-8
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-iodo-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

: 944158-28-5
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(1-bromopropyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / 14 h / 100 °C

2: formic acid / platinum(IV) oxide / water / 22 h / 60 °C

3: diethyl ether / 0.17 h / -78 °C

4: carbon tetrabromide; triphenylphosphine / dichloromethane / 72 h / 0 - 20 °C

With formic acid; carbon tetrabromide; triphenylphosphine; platinum(IV) oxide; In diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 702641-04-1
2-iodo-5-(trifluoromethyl)benzoic acid

: 944158-28-5
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(1-bromopropyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: borane-THF / tetrahydrofuran / 1.5 h / 0 °C / Heating / reflux

2: carbon tetrabromide; triphenylphosphine / dichloromethane / 62 h / 0 - 20 °C

3: sodium hydride / 18 h / 20 °C

4: N,N-dimethyl-formamide / 14 h / 100 °C

5: formic acid / platinum(IV) oxide / water / 22 h / 60 °C

6: diethyl ether / 0.17 h / -78 °C

7: carbon tetrabromide; triphenylphosphine / dichloromethane / 72 h / 0 - 20 °C

With formic acid; borane-THF; carbon tetrabromide; sodium hydride; triphenylphosphine; platinum(IV) oxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;