2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-4-(trifluoromethyl)benzaldehyde

Base Information

• Chemical Name: 2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-4-(trifluoromethyl)benzaldehyde
• CAS No.: 943917-30-4
• Molecular Formula: C₂₁H₁₄F₉NO₃
• Molecular Weight: 499.333
• Mol file: 943917-30-4.mol

Synonyms:2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-4-(trifluoromethyl)benzaldehyde

Chemical Property of 2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-4-(trifluoromethyl)benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-4-(trifluoromethyl)benzaldehyde

There total 12 articles about 2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-4-(trifluoromethyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(hydroxymethyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one (943917-29-1) → 2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-4-(trifluoromethyl)benzaldehyde (943917-30-4)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

2-iodo-5-(trifluoromethyl)benzoic acid (702641-04-1) → 2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-4-(trifluoromethyl)benzaldehyde (943917-30-4)

Guidance literature:

Multi-step reaction with 5 steps

1: borane-THF / tetrahydrofuran / 1.5 h / 0 °C / Heating / reflux

2: carbon tetrabromide; triphenylphosphine / dichloromethane / 62 h / 0 - 20 °C

3: sodium hydride / 18 h / 20 °C

4: N,N-dimethyl-formamide / 14 h / 100 °C

5: formic acid / platinum(IV) oxide / water / 22 h / 60 °C

With formic acid; borane-THF; carbon tetrabromide; sodium hydride; triphenylphosphine; platinum(IV) oxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

2-(bromomethyl)-1-iodo-4-(trifluoromethyl)benzene (702641-06-3) → 2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-4-(trifluoromethyl)benzaldehyde (943917-30-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / 18 h / 20 °C

2: N,N-dimethyl-formamide / 14 h / 100 °C

3: formic acid / platinum(IV) oxide / water / 22 h / 60 °C

With formic acid; sodium hydride; platinum(IV) oxide; In water; N,N-dimethyl-formamide;

upstream raw materials:

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(hydroxymethyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-iodo-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

2-iodo-5-(trifluoromethyl)benzoic acid

2-(bromomethyl)-1-iodo-4-(trifluoromethyl)benzene

Downstream raw materials:

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(bromomethyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(1-bromopropyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-butyryl-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one