Technology Process of ethyl N-{[3-bromo-7-(3-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate
There total 10 articles about ethyl N-{[3-bromo-7-(3-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-bromo-7-(3-fluorophenyl)-6-hydroxy-5-quinoxalinecarboxylic acid;
With
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
dichloromethane;
for 0.166667h;
glycine ethyl ester hydrochloride;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 10 steps
1: sulfuric acid; nitric acid / 0 - 20 °C
2: ammonium hydroxide / ethanol; water / 20 °C
3: sodium hydride / mineral oil / 1 h / 0 - 20 °C
4: bromine / dichloromethane / 0.5 h / 20 °C
5: tin(II) chloride dihdyrate; ethanol / 2 h / Reflux
6: methanol; dichloromethane; toluene / 2 h / 80 °C
7: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere
8: trichlorophosphate / 2 h / 115 °C
9: boron tribromide / dichloromethane / 0 - 20 °C
10: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.17 h
With
ammonium hydroxide; tin(II) chloride dihdyrate; ethanol; sulfuric acid; bromine; nitric acid; boron tribromide; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: sodium hydride / mineral oil / 1 h / 0 - 20 °C
2: bromine / dichloromethane / 0.5 h / 20 °C
3: tin(II) chloride dihdyrate; ethanol / 2 h / Reflux
4: methanol; dichloromethane; toluene / 2 h / 80 °C
5: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere
6: trichlorophosphate / 2 h / 115 °C
7: boron tribromide / dichloromethane / 0 - 20 °C
8: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.17 h
With
tin(II) chloride dihdyrate; ethanol; bromine; boron tribromide; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; methanol; dichloromethane; toluene; mineral oil;
