N-{[7-(3-fluorophenyl)-3-(4-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine

Base Information

Chemical Name:N-{[7-(3-fluorophenyl)-3-(4-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine
CAS No.:1160685-99-3
Molecular Formula:C₂₃H₁₅F₂N₃O₄
Molecular Weight:435.387
Hs Code.:

Synonyms:N-{[7-(3-fluorophenyl)-3-(4-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine

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Chemical Property of N-{[7-(3-fluorophenyl)-3-(4-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine

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Technology Process of N-{[7-(3-fluorophenyl)-3-(4-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine

There total 11 articles about N-{[7-(3-fluorophenyl)-3-(4-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.8%

: 1160685-74-4
ethyl N-{[3-bromo-7-(3-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate

: 1765-93-1
4-fluoroboronic acid

: 1160685-99-3
N-{[7-(3-fluorophenyl)-3-(4-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine

Guidance literature:: ethyl N-{[3-bromo-7-(3-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate; 4-fluoroboronic acid; With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile; at 120 ℃; for 1h; Inert atmosphere; Microwave irradiation;

With water; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; for 0.166667h;

With trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 13671-00-6
methyl 2,6-difluorobenzoate

: 1160685-99-3
N-{[7-(3-fluorophenyl)-3-(4-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine

Guidance literature:: Multi-step reaction with 11 steps

1.1: sulfuric acid; nitric acid / 0 - 20 °C

2.1: ammonium hydroxide / ethanol; water / 20 °C

3.1: sodium hydride / mineral oil / 1 h / 0 - 20 °C

4.1: bromine / dichloromethane / 0.5 h / 20 °C

5.1: tin(II) chloride dihdyrate; ethanol / 2 h / Reflux

6.1: methanol; dichloromethane; toluene / 2 h / 80 °C

7.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere

8.1: trichlorophosphate / 2 h / 115 °C

9.1: boron tribromide / dichloromethane / 0 - 20 °C

10.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.17 h

11.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; 1,4-dioxane; water; acetonitrile / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

11.2: 0.17 h

With ammonium hydroxide; tin(II) chloride dihdyrate; ethanol; sulfuric acid; bromine; nitric acid; boron tribromide; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene; acetonitrile; mineral oil;

Reference yield:

: 346691-23-4
methyl 2-amino-6-fluoro-3-nitrobenzoate

: 1160685-99-3
N-{[7-(3-fluorophenyl)-3-(4-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / mineral oil / 1 h / 0 - 20 °C

2.1: bromine / dichloromethane / 0.5 h / 20 °C

3.1: tin(II) chloride dihdyrate; ethanol / 2 h / Reflux

4.1: methanol; dichloromethane; toluene / 2 h / 80 °C

5.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere

6.1: trichlorophosphate / 2 h / 115 °C

7.1: boron tribromide / dichloromethane / 0 - 20 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.17 h

9.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; 1,4-dioxane; water; acetonitrile / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

9.2: 0.17 h

With tin(II) chloride dihdyrate; ethanol; bromine; boron tribromide; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; toluene; acetonitrile; mineral oil;