tert-butyl (2S,3S)-4-(benzyloxy)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]butanoate

Base Information

Chemical Name:tert-butyl (2S,3S)-4-(benzyloxy)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]butanoate
CAS No.:1401228-02-1
Molecular Formula:C₃₅H₃₆F₂N₂O₅S
Molecular Weight:634.744
Hs Code.:

Synonyms:tert-butyl (2S,3S)-4-(benzyloxy)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]butanoate

Suppliers and Price of tert-butyl (2S,3S)-4-(benzyloxy)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]butanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl (2S,3S)-4-(benzyloxy)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]butanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (2S,3S)-4-(benzyloxy)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]butanoate

There total 2 articles about tert-butyl (2S,3S)-4-(benzyloxy)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1215220-67-9
N-[2-benzyloxy-1-(toluene-4-sulfonyl)ethyl]-4-methylbenzenesulfonamide

: N-[bis(4-fluorophenyl)methylene]glycine tert-butyl ester

: 1401228-02-1
tert-butyl (2S,3S)-4-(benzyloxy)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]butanoate

Guidance literature:: With tetrakis(actonitrile)copper(I) hexafluorophosphate; (Rp)-2-(tert-butylthio)-1-(diphenyl-phosphino)ferrocene; caesium carbonate; In tetrahydrofuran; at -20 ℃; for 19h; enantioselective reaction; Inert atmosphere;
DOI:10.1039/c2cc35160a

Reference yield:

: 60656-87-3
benzyloxyacetoaldehyde

: 70-55-3
toluene-4-sulfonamide

: 1401228-02-1
tert-butyl (2S,3S)-4-(benzyloxy)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: formic acid / water / 24 h / 0 - 20 °C

2: (Rp)-2-(tert-butylthio)-1-(diphenyl-phosphino)ferrocene; tetrakis(actonitrile)copper(I) hexafluorophosphate; caesium carbonate / tetrahydrofuran / 19 h / -20 °C / Inert atmosphere

With formic acid; tetrakis(actonitrile)copper(I) hexafluorophosphate; (Rp)-2-(tert-butylthio)-1-(diphenyl-phosphino)ferrocene; caesium carbonate; In tetrahydrofuran; water; 1: |Mannich Aminomethylation / 2: |Mannich Aminomethylation;
DOI:10.1039/c2cc35160a