3-(tert-Butyldiphenylsilanyloxy)-8-(dimethoxyphosphoryl)-7-oxooctanoic acid

Base Information

Chemical Name:3-(tert-Butyldiphenylsilanyloxy)-8-(dimethoxyphosphoryl)-7-oxooctanoic acid
CAS No.:203520-36-9
Molecular Formula:C₂₆H₃₇O₇PSi
Molecular Weight:520.635
Hs Code.:

Synonyms:3-(tert-Butyldiphenylsilanyloxy)-8-(dimethoxyphosphoryl)-7-oxooctanoic acid

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Chemical Property of 3-(tert-Butyldiphenylsilanyloxy)-8-(dimethoxyphosphoryl)-7-oxooctanoic acid

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Technology Process of 3-(tert-Butyldiphenylsilanyloxy)-8-(dimethoxyphosphoryl)-7-oxooctanoic acid

There total 9 articles about 3-(tert-Butyldiphenylsilanyloxy)-8-(dimethoxyphosphoryl)-7-oxooctanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 203520-34-7
3-(tert-Butyldiphenylsilanyloxy)-8-(dimethoxyphosphoryl)-7-oxooctanoic acid benzyl ester

: 203520-36-9
3-(tert-Butyldiphenylsilanyloxy)-8-(dimethoxyphosphoryl)-7-oxooctanoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate;
DOI:10.1055/s-1997-1055

Reference yield:

: 112440-75-2
(R)-3-hydroxy-hept-6-enoic acid

: 203520-36-9
3-(tert-Butyldiphenylsilanyloxy)-8-(dimethoxyphosphoryl)-7-oxooctanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: aq. NaHCO₃ / CH₂Cl₂ / 72 h / 20 °C

2.1: 81 percent / imidazole / dimethylformamide / 16 h / 20 °C

3.1: borane-dimethyl sulfide complex / tetrahydrofuran / 3 h / 20 °C

3.2: 78 percent / aq. H₂O₂; NaOH / tetrahydrofuran / 2 h / 0 °C

4.1: 78 percent / pyridinium dichromate / CH₂Cl₂ / 23 h / 20 °C

5.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

5.2: 55 percent / tetrahydrofuran; hexane / 2 h / -78 °C

6.1: 84 percent / pyridinium dichromate / dimethylformamide / 36 h / 20 °C

7.1: 98 percent / H₂ / 10percent Pd/C / ethyl acetate / 24 h

With 1H-imidazole; dipyridinium dichromate; n-butyllithium; dimethylsulfide borane complex; hydrogen; sodium hydrogencarbonate; 10percent Pd/C; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1.1: Acylation / 2.1: Substitution / 3.1: Addition / 3.2: Oxidation / 4.1: Oxidation / 5.1: Metallation / 5.2: Addition / 6.1: Oxidation / 7.1: Hydrogenolysis;
DOI:10.1039/b000751j

Reference yield:

: 203520-29-0
3-Hydroxyhept-6-enoic acid benzyl ester

: 203520-36-9
3-(tert-Butyldiphenylsilanyloxy)-8-(dimethoxyphosphoryl)-7-oxooctanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: 81 percent / imidazole / dimethylformamide / 16 h / 20 °C

2.1: borane-dimethyl sulfide complex / tetrahydrofuran / 3 h / 20 °C

2.2: 78 percent / aq. H₂O₂; NaOH / tetrahydrofuran / 2 h / 0 °C

3.1: 78 percent / pyridinium dichromate / CH₂Cl₂ / 23 h / 20 °C

4.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

4.2: 55 percent / tetrahydrofuran; hexane / 2 h / -78 °C

5.1: 84 percent / pyridinium dichromate / dimethylformamide / 36 h / 20 °C

6.1: 98 percent / H₂ / 10percent Pd/C / ethyl acetate / 24 h

With 1H-imidazole; dipyridinium dichromate; n-butyllithium; dimethylsulfide borane complex; hydrogen; 10percent Pd/C; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1.1: Substitution / 2.1: Addition / 2.2: Oxidation / 3.1: Oxidation / 4.1: Metallation / 4.2: Addition / 5.1: Oxidation / 6.1: Hydrogenolysis;
DOI:10.1039/b000751j