3-(tert-Butyldiphenylsilanyloxy)-8-(dimethoxyphosphoryl)-7-oxooctanoic acid benzyl ester

Base Information

Chemical Name:3-(tert-Butyldiphenylsilanyloxy)-8-(dimethoxyphosphoryl)-7-oxooctanoic acid benzyl ester
CAS No.:203520-34-7
Molecular Formula:C₃₃H₄₃O₇PSi
Molecular Weight:610.759
Hs Code.:

Synonyms:3-(tert-Butyldiphenylsilanyloxy)-8-(dimethoxyphosphoryl)-7-oxooctanoic acid benzyl ester

Suppliers and Price of 3-(tert-Butyldiphenylsilanyloxy)-8-(dimethoxyphosphoryl)-7-oxooctanoic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(tert-Butyldiphenylsilanyloxy)-8-(dimethoxyphosphoryl)-7-oxooctanoic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(tert-Butyldiphenylsilanyloxy)-8-(dimethoxyphosphoryl)-7-oxooctanoic acid benzyl ester

There total 9 articles about 3-(tert-Butyldiphenylsilanyloxy)-8-(dimethoxyphosphoryl)-7-oxooctanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 203520-33-6
3-(tert-Butyldiphenylsilanyloxy)-8-(dimethoxyphosphoryl)-7-hydroxyheptanoic acid benzyl ester

: 203520-34-7
3-(tert-Butyldiphenylsilanyloxy)-8-(dimethoxyphosphoryl)-7-oxooctanoic acid benzyl ester

Guidance literature:: With dipyridinium dichromate; In N,N-dimethyl-formamide; for 48h;
DOI:10.1055/s-1997-1055

Reference yield:

: 112440-75-2
(R)-3-hydroxy-hept-6-enoic acid

: 203520-34-7
3-(tert-Butyldiphenylsilanyloxy)-8-(dimethoxyphosphoryl)-7-oxooctanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: aq. NaHCO₃ / CH₂Cl₂ / 72 h / 20 °C

2.1: 81 percent / imidazole / dimethylformamide / 16 h / 20 °C

3.1: borane-dimethyl sulfide complex / tetrahydrofuran / 3 h / 20 °C

3.2: 78 percent / aq. H₂O₂; NaOH / tetrahydrofuran / 2 h / 0 °C

4.1: 78 percent / pyridinium dichromate / CH₂Cl₂ / 23 h / 20 °C

5.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

5.2: 55 percent / tetrahydrofuran; hexane / 2 h / -78 °C

6.1: 84 percent / pyridinium dichromate / dimethylformamide / 36 h / 20 °C

With 1H-imidazole; dipyridinium dichromate; n-butyllithium; dimethylsulfide borane complex; sodium hydrogencarbonate; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; 1.1: Acylation / 2.1: Substitution / 3.1: Addition / 3.2: Oxidation / 4.1: Oxidation / 5.1: Metallation / 5.2: Addition / 6.1: Oxidation;
DOI:10.1039/b000751j

Reference yield:

: 100-39-0
benzyl bromide

: 203520-34-7
3-(tert-Butyldiphenylsilanyloxy)-8-(dimethoxyphosphoryl)-7-oxooctanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 70 percent / NaHCO₃ / aliquat-336 / CH₂Cl₂; H₂O

2: 91 percent / imidazole / dimethylformamide / 14 h / Ambient temperature

3: 78 percent / BH₃*DMS, H₂O₂, NaOH

4: 84 percent / PDC / CH₂Cl₂ / 12 h / Ambient temperature

5: 55 percent / BuLi

6: 84 percent / PDC / dimethylformamide / 48 h

With 1H-imidazole; sodium hydroxide; dipyridinium dichromate; n-butyllithium; dimethylsulfide borane complex; dihydrogen peroxide; sodium hydrogencarbonate; Aliquat 336; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1055/s-1997-1055