3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-phenyl-1H-1,2,3-triazol-4-yl)estradiol

Base Information

• Chemical Name: 3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-phenyl-1H-1,2,3-triazol-4-yl)estradiol
• CAS No.: 1620909-80-9
• Molecular Formula: C₃₃H₄₅N₃O₃Si
• Molecular Weight: 559.824
• Mol file: 1620909-80-9.mol

Synonyms:3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-phenyl-1H-1,2,3-triazol-4-yl)estradiol

Chemical Property of 3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-phenyl-1H-1,2,3-triazol-4-yl)estradiol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-phenyl-1H-1,2,3-triazol-4-yl)estradiol

There total 4 articles about 3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-phenyl-1H-1,2,3-triazol-4-yl)estradiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-O-(tert-butyl)dimethylsilyl-2-methoxyethynylestradiol (1620910-47-5) + Phenyl azide (622-37-7) → 3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-phenyl-1H-1,2,3-triazol-4-yl)estradiol (1620909-80-9)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 50 ℃; for 24h;

DOI:10.1016/j.steroids.2014.05.020

Reference yield:

2-methoxyestrone (362-08-3,7683-30-9) → 3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-phenyl-1H-1,2,3-triazol-4-yl)estradiol (1620909-80-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

2: tetrahydrofuran / 4.75 h / 0 - 20 °C

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 24 h / 50 °C

With 1H-imidazole; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/j.steroids.2014.05.020

Reference yield:

3-O-(tert-butyl)dimethylsilyl-2-methoxyestrone (767352-05-6) → 3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-phenyl-1H-1,2,3-triazol-4-yl)estradiol (1620909-80-9)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 4.75 h / 0 - 20 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 24 h / 50 °C

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In tetrahydrofuran; water; tert-butyl alcohol;

DOI:10.1016/j.steroids.2014.05.020

upstream raw materials:

2-methoxyestrone

3-O-(tert-butyl)dimethylsilyl-2-methoxyestrone

3-O-(tert-butyl)dimethylsilyl-2-methoxyethynylestradiol

Phenyl azide

Downstream raw materials:

2-methoxy-17-(1-phenyl-1H-1,2,3-triazol-4-yl)estradiol