(R)-2-(tert-butyldimethylsilyloxy)-2-(pentafluorophenyl)acetonitrile

Base Information

• Chemical Name: (R)-2-(tert-butyldimethylsilyloxy)-2-(pentafluorophenyl)acetonitrile
• CAS No.: 271788-76-2
• Molecular Formula: C₁₄H₁₆F₅NOSi
• Molecular Weight: 337.365
• Mol file: 271788-76-2.mol

Synonyms:(R)-2-(tert-butyldimethylsilyloxy)-2-(pentafluorophenyl)acetonitrile

Chemical Property of (R)-2-(tert-butyldimethylsilyloxy)-2-(pentafluorophenyl)acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-(tert-butyldimethylsilyloxy)-2-(pentafluorophenyl)acetonitrile

There total 1 articles about (R)-2-(tert-butyldimethylsilyloxy)-2-(pentafluorophenyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

t-butyldimethylsiyl triflate (69739-34-0) + (R)-2-hydroxy-2-(pentafluorophenyl)acetonitrile (99530-27-5) → (R)-2-(tert-butyldimethylsilyloxy)-2-(pentafluorophenyl)acetonitrile (271788-76-2)

Guidance literature:

With dmap; In dichloromethane; at 0 ℃; for 2.5h;

DOI:10.1016/S0022-1139(03)00089-7

Reference yield:

bromopentafluorobenzene (344-04-7) + (R)-2-(tert-butyldimethylsilyloxy)-2-(pentafluorophenyl)acetonitrile (271788-76-2) → (R)-2-(tert-butyldimethylsiloxy)-1,2-bis(pentafluorophenyl)ethan-1-one

Guidance literature:

bromopentafluorobenzene; With n-butyllithium; In diethyl ether; hexane; at -78 ℃;

(R)-2-(tert-butyldimethylsilyloxy)-2-(pentafluorophenyl)acetonitrile; In diethyl ether; hexane; at -85 ℃;

With hydrogenchloride; In diethyl ether; ethanol; hexane; at 0 - 5 ℃;

DOI:10.1021/jo9918551

Reference yield:

phenyllithium (591-51-5) + (R)-2-(tert-butyldimethylsilyloxy)-2-(pentafluorophenyl)acetonitrile (271788-76-2) → 2-(tert-butyl-dimethyl-silanyloxy)-2-pentafluorophenyl-1-phenyl-ethylideneamine

Guidance literature:

With chloro-trimethyl-silane; In diethyl ether; cyclohexane; at -85 ℃; for 1.5h;

DOI:10.1016/S0022-1139(03)00089-7

upstream raw materials:

t-butyldimethylsiyl triflate

(R)-2-hydroxy-2-(pentafluorophenyl)acetonitrile

Downstream raw materials:

(1R,2S)-2-amino-1-(pentafluorophenyl)-2-phenylethanol

(1R,2S)-2-(tert-butyldimethylsiloxy)-2-(pentafluorophenyl)-1-phenylethylamine