(1R,2S)-2-(tert-butyldimethylsiloxy)-2-(pentafluorophenyl)-1-phenylethylamine

Base Information

Chemical Name:(1R,2S)-2-(tert-butyldimethylsiloxy)-2-(pentafluorophenyl)-1-phenylethylamine
CAS No.:615557-66-9
Molecular Formula:C₂₀H₂₄F₅NOSi
Molecular Weight:417.494
Hs Code.:

Synonyms:(1R,2S)-2-(tert-butyldimethylsiloxy)-2-(pentafluorophenyl)-1-phenylethylamine

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Chemical Property of (1R,2S)-2-(tert-butyldimethylsiloxy)-2-(pentafluorophenyl)-1-phenylethylamine

Chemical Property:

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Technology Process of (1R,2S)-2-(tert-butyldimethylsiloxy)-2-(pentafluorophenyl)-1-phenylethylamine

There total 4 articles about (1R,2S)-2-(tert-butyldimethylsiloxy)-2-(pentafluorophenyl)-1-phenylethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(tert-butyl-dimethyl-silanyloxy)-2-pentafluorophenyl-1-phenyl-ethylideneamine

: (1R,2R)-2-(tert-butyldimethylsiloxy)-2-(pentafluorophenyl)-1-phenylethylamine

: 615557-66-9
(1R,2S)-2-(tert-butyldimethylsiloxy)-2-(pentafluorophenyl)-1-phenylethylamine

Guidance literature:: With sodium tetrahydroborate; In diethyl ether; ethanol; cyclohexane; at 0 ℃; for 1.5h;
DOI:10.1016/S0022-1139(03)00089-7

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 615557-66-9
(1R,2S)-2-(tert-butyldimethylsiloxy)-2-(pentafluorophenyl)-1-phenylethylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / DMAP / CH₂Cl₂ / 2.5 h / 0 °C

2: Me₃SiCl / diethyl ether; cyclohexane / 1.5 h / -85 °C

3: 1.30 g / NaBH₄ / diethyl ether; cyclohexane; ethanol / 1.5 h / 0 °C

With dmap; sodium tetrahydroborate; chloro-trimethyl-silane; In diethyl ether; ethanol; dichloromethane; cyclohexane;
DOI:10.1016/S0022-1139(03)00089-7

Reference yield:

: 271788-76-2
(R)-2-(tert-butyldimethylsilyloxy)-2-(pentafluorophenyl)acetonitrile

: 615557-66-9
(1R,2S)-2-(tert-butyldimethylsiloxy)-2-(pentafluorophenyl)-1-phenylethylamine

Guidance literature:: Multi-step reaction with 2 steps

1: Me₃SiCl / diethyl ether; cyclohexane / 1.5 h / -85 °C

2: 1.30 g / NaBH₄ / diethyl ether; cyclohexane; ethanol / 1.5 h / 0 °C

With sodium tetrahydroborate; chloro-trimethyl-silane; In diethyl ether; ethanol; cyclohexane;
DOI:10.1016/S0022-1139(03)00089-7