(R)-tert-butyl 3-(4-fluorophenyl)-2-oxo-3-(3-oxobutyl)indoline-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 3-(4-fluorophenyl)-2-oxo-3-(3-oxobutyl)indoline-1-carboxylate
CAS No.:1393474-96-8
Molecular Formula:C₂₃H₂₄FNO₄
Molecular Weight:397.446
Hs Code.:

Synonyms:(R)-tert-butyl 3-(4-fluorophenyl)-2-oxo-3-(3-oxobutyl)indoline-1-carboxylate

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Chemical Property of (R)-tert-butyl 3-(4-fluorophenyl)-2-oxo-3-(3-oxobutyl)indoline-1-carboxylate

Chemical Property:

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Technology Process of (R)-tert-butyl 3-(4-fluorophenyl)-2-oxo-3-(3-oxobutyl)indoline-1-carboxylate

There total 2 articles about (R)-tert-butyl 3-(4-fluorophenyl)-2-oxo-3-(3-oxobutyl)indoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 862907-06-0
tert-butyl 3-(4-fluorophenyl)-2-oxoindoline-1-carboxylate

: 78-94-4,25038-87-3
methyl vinyl ketone

: 1393474-96-8
(R)-tert-butyl 3-(4-fluorophenyl)-2-oxo-3-(3-oxobutyl)indoline-1-carboxylate

Guidance literature:: tert-butyl 3-(4-fluorophenyl)-2-oxoindoline-1-carboxylate; With C₂₆H₂₄F₆NOP; In chloroform; at -55 ℃;

methyl vinyl ketone; In chloroform; at -55 ℃; for 24h; enantioselective reaction;
DOI:10.1002/anie.201208285

Reference yield:

: 862907-06-0
tert-butyl 3-(4-fluorophenyl)-2-oxoindoline-1-carboxylate

: 78-94-4,25038-87-3
methyl vinyl ketone

: 1175713-14-0
C₂₃H₂₄FNO₄

: 1393474-96-8
(R)-tert-butyl 3-(4-fluorophenyl)-2-oxo-3-(3-oxobutyl)indoline-1-carboxylate

Guidance literature:: With C₄₅H₃₃F₆N₃S; In toluene; at 20 ℃; for 2h; optical yield given as %ee; enantioselective reaction;
DOI:10.3390/molecules17067523