4-cyano-4-phenyl-hexanoic acid [2-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amide

Base Information

Chemical Name:4-cyano-4-phenyl-hexanoic acid [2-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amide
CAS No.:929685-30-3
Molecular Formula:C₂₄H₃₀N₂O₃
Molecular Weight:394.514
Hs Code.:

Synonyms:4-cyano-4-phenyl-hexanoic acid [2-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amide

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Chemical Property of 4-cyano-4-phenyl-hexanoic acid [2-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amide

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Technology Process of 4-cyano-4-phenyl-hexanoic acid [2-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amide

There total 4 articles about 4-cyano-4-phenyl-hexanoic acid [2-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 929685-27-8
4-cyano-4-phenyl-hexanoic acid [2-(3,4-dimethoxy-phenyl)-ethyl]-amide

: 74-88-4
methyl iodide

: 929685-30-3
4-cyano-4-phenyl-hexanoic acid [2-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amide

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1002/chem.200600811

Reference yield:

: 13312-96-4
2-ethyl-2-phenylbut-3-enenitrile

: 929685-30-3
4-cyano-4-phenyl-hexanoic acid [2-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / triruthenium dodecacarbonyl / dimethylformamide / 17 h / 120 °C

2: 75 percent / sodium 1,1,1,3,3,3-hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C

With sodium hexamethyldisilazane; triruthenium dodecacarbonyl; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/chem.200600811

Reference yield:

: 19472-74-3
2-(2-bromophenyl)acetonitrile

: 929685-30-3
4-cyano-4-phenyl-hexanoic acid [2-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium bis(trimethylsilyl)amide; 1,3-dimethyl-3,4,5,6-tetrahydro-2-(1H)-pyrimidone / tetrahydrofuran / 0.5 h / 20 °C

1.2: 92 percent / tetrahydrofuran / 1 h

2.1: 77 percent / tris(5-fluoro-2-methylphenyl)phosphane; potassium carbonate / palladium acetate / dimethylformamide / 0.75 h / 100 °C

3.1: 69 percent / triruthenium dodecacarbonyl / dimethylformamide / 17 h / 120 °C

4.1: 75 percent / sodium 1,1,1,3,3,3-hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C

With tris(5-fluoro-2-methylphenyl)phosphane; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium hexamethyldisilazane; potassium carbonate; lithium hexamethyldisilazane; triruthenium dodecacarbonyl; palladium diacetate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/chem.200600811