(Rp)-8-(4-fluorophenyl)adenosine-2'O-(tert-butyldimethylsilyl)-3',5'-cyclic N-benzylphosphoramidate

Base Information

Chemical Name:(Rp)-8-(4-fluorophenyl)adenosine-2'O-(tert-butyldimethylsilyl)-3',5'-cyclic N-benzylphosphoramidate
CAS No.:872025-88-2
Molecular Formula:C₂₉H₃₆FN₆O₅PSi
Molecular Weight:626.7
Hs Code.:

Synonyms:(Rp)-8-(4-fluorophenyl)adenosine-2'O-(tert-butyldimethylsilyl)-3',5'-cyclic N-benzylphosphoramidate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Rp)-8-(4-fluorophenyl)adenosine-2'O-(tert-butyldimethylsilyl)-3',5'-cyclic N-benzylphosphoramidate

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Technology Process of (Rp)-8-(4-fluorophenyl)adenosine-2'O-(tert-butyldimethylsilyl)-3',5'-cyclic N-benzylphosphoramidate

There total 1 articles about (Rp)-8-(4-fluorophenyl)adenosine-2'O-(tert-butyldimethylsilyl)-3',5'-cyclic N-benzylphosphoramidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 872025-83-7
(S_P)-8-bromoadenosine-2'-O-(tert-butyldimethylsilyl)-3',5'-cyclic N-benzylphosphoramidate

: 17151-47-2
tributyl(4-fluorophenyl)stannane

: 872025-88-2
(Rp)-8-(4-fluorophenyl)adenosine-2'O-(tert-butyldimethylsilyl)-3',5'-cyclic N-benzylphosphoramidate

Guidance literature:: palladium diacetate; triphenylphosphine; In 1-methyl-pyrrolidin-2-one; at 50 - 135 ℃; for 8h;

Reference yield:

: 872025-88-2
(Rp)-8-(4-fluorophenyl)adenosine-2'O-(tert-butyldimethylsilyl)-3',5'-cyclic N-benzylphosphoramidate

: (Rp)-8-(4-fluorophenyl)-2'O-(tert-butyldimethylsilyl)-3',5'-cyclic phosphorothioic acid

Guidance literature:: (Rp)-8-(4-fluorophenyl)adenosine-2'O-(tert-butyldimethylsilyl)-3',5'-cyclic N-benzylphosphoramidate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

With carbon disulfide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2.33333h;

With hydrogenchloride; water; at 0 ℃;