mono(1-(4-prop-2-ynyloxyphenyl)-2-methoxycarbonyl-2-propenyl) glutaric acid (5S)-carboxy-5-[bis(hydroxycarbonylmethyl)amino]pentylamide

Base Information

• Chemical Name: mono(1-(4-prop-2-ynyloxyphenyl)-2-methoxycarbonyl-2-propenyl) glutaric acid (5S)-carboxy-5-[bis(hydroxycarbonylmethyl)amino]pentylamide
• CAS No.: 1456890-66-6
• Molecular Formula: C₂₉H₃₆N₂O₁₂
• Molecular Weight: 604.611
• Mol file: 1456890-66-6.mol

Synonyms:mono(1-(4-prop-2-ynyloxyphenyl)-2-methoxycarbonyl-2-propenyl) glutaric acid (5S)-carboxy-5-[bis(hydroxycarbonylmethyl)amino]pentylamide

Chemical Property of mono(1-(4-prop-2-ynyloxyphenyl)-2-methoxycarbonyl-2-propenyl) glutaric acid (5S)-carboxy-5-[bis(hydroxycarbonylmethyl)amino]pentylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of mono(1-(4-prop-2-ynyloxyphenyl)-2-methoxycarbonyl-2-propenyl) glutaric acid (5S)-carboxy-5-[bis(hydroxycarbonylmethyl)amino]pentylamide

There total 5 articles about mono(1-(4-prop-2-ynyloxyphenyl)-2-methoxycarbonyl-2-propenyl) glutaric acid (5S)-carboxy-5-[bis(hydroxycarbonylmethyl)amino]pentylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

mono(1-(4-prop-2-ynyloxy-phenyl)-2-methoxycarbonyl-2-propenyl)glutaric acid N-hydroxy succinimide ester (1456890-65-5) + N,N-bis(carboxymethyl)-L-lysine (113231-05-3) → mono(1-(4-prop-2-ynyloxyphenyl)-2-methoxycarbonyl-2-propenyl) glutaric acid (5S)-carboxy-5-[bis(hydroxycarbonylmethyl)amino]pentylamide (1456890-66-6)

Guidance literature:

With triethylamine; In methanol; at 0 - 20 ℃;

DOI:10.1039/c3cc43271h

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → mono(1-(4-prop-2-ynyloxyphenyl)-2-methoxycarbonyl-2-propenyl) glutaric acid (5S)-carboxy-5-[bis(hydroxycarbonylmethyl)amino]pentylamide (1456890-66-6)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 6 h / Reflux

2: 1,4-diaza-bicyclo[2.2.2]octane / methanol / 48 h / 20 °C / Darkness

3: pyridine / dichloromethane / 4 h / 0 - 20 °C

4: triethylamine / methanol / 0 - 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; potassium carbonate; triethylamine; In methanol; dichloromethane; acetone;

DOI:10.1039/c3cc43271h

Reference yield:

4-(prop-2-ynyloxy)benzaldehyde (5651-86-5) → mono(1-(4-prop-2-ynyloxyphenyl)-2-methoxycarbonyl-2-propenyl) glutaric acid (5S)-carboxy-5-[bis(hydroxycarbonylmethyl)amino]pentylamide (1456890-66-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / methanol / 48 h / 20 °C / Darkness

2: pyridine / dichloromethane / 4 h / 0 - 20 °C

3: triethylamine / methanol / 0 - 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; triethylamine; In methanol; dichloromethane;

DOI:10.1039/c3cc43271h

upstream raw materials:

mono(1-(4-prop-2-ynyloxy-phenyl)-2-methoxycarbonyl-2-propenyl)glutaric acid N-hydroxy succinimide ester

N,N-bis(carboxymethyl)-L-lysine

4-hydroxy-benzaldehyde

4-(prop-2-ynyloxy)benzaldehyde