N³-[3,5-dichloro-4-(4-methanesulfonylphenoxy)phenyl]-1H-[1,2,4]triazole-3,5-diamine

Base Information

• Chemical Name: N³-[3,5-dichloro-4-(4-methanesulfonylphenoxy)phenyl]-1H-[1,2,4]triazole-3,5-diamine
• CAS No.: 1620782-69-5
• Molecular Formula: C₁₅H₁₃Cl₂N₅O₃S
• Molecular Weight: 414.272

Synonyms:N³-[3,5-dichloro-4-(4-methanesulfonylphenoxy)phenyl]-1H-[1,2,4]triazole-3,5-diamine

Chemical Property of N³-[3,5-dichloro-4-(4-methanesulfonylphenoxy)phenyl]-1H-[1,2,4]triazole-3,5-diamine

Chemical Property:

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Technology Process of N³-[3,5-dichloro-4-(4-methanesulfonylphenoxy)phenyl]-1H-[1,2,4]triazole-3,5-diamine

There total 5 articles about N³-[3,5-dichloro-4-(4-methanesulfonylphenoxy)phenyl]-1H-[1,2,4]triazole-3,5-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(E)-methyl N'-cyano-N-(3,5-dichloro-4-(4-(methylsulfonyl)phenoxy)phenyl)carbamimidothioate (1620878-58-1) → N3-[3,5-dichloro-4-(4-methanesulfonylphenoxy)phenyl]-1H-[1,2,4]triazole-3,5-diamine (1620782-69-5)

Guidance literature:

With hydrazine; In tetrahydrofuran; methanol; at 20 ℃;

Reference yield:

3,5-dichloro-4-fluoro-nitrobenzene (3107-19-5) → N3-[3,5-dichloro-4-(4-methanesulfonylphenoxy)phenyl]-1H-[1,2,4]triazole-3,5-diamine (1620782-69-5)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 110 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h / 20 °C / 2585.81 Torr

3: pyridine / 3 h / Reflux

4: hydrazine / methanol; tetrahydrofuran / 20 °C

With pyridine; palladium 10% on activated carbon; hydrogen; potassium carbonate; hydrazine; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

4-methanesulfonyl-phenol (14763-60-1) → N3-[3,5-dichloro-4-(4-methanesulfonylphenoxy)phenyl]-1H-[1,2,4]triazole-3,5-diamine (1620782-69-5)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 110 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h / 20 °C / 2585.81 Torr

3: pyridine / 3 h / Reflux

4: hydrazine / methanol; tetrahydrofuran / 20 °C

With pyridine; palladium 10% on activated carbon; hydrogen; potassium carbonate; hydrazine; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

3,5-dichloro-4-fluoro-nitrobenzene

1,3-dichloro-2-(4-methanesulfonylphenoxy)-5-nitrobenzene

4-methanesulfonyl-phenol

1,3-dichloro-2-(4-methanesulfonylphenoxy)-5-aminobenzene

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