ethyl 2-((2-chloro-5-methyl-4-pyrimidinyl){[(1.1-dimethylethyl)oxy]carbonyl}amino)benzoate

Base Information

• Chemical Name: ethyl 2-((2-chloro-5-methyl-4-pyrimidinyl){[(1.1-dimethylethyl)oxy]carbonyl}amino)benzoate
• CAS No.: 1089653-99-5
• Molecular Formula: C₁₉H₂₂ClN₃O₄
• Molecular Weight: 391.854
• Mol file: 1089653-99-5.mol

Synonyms:ethyl 2-((2-chloro-5-methyl-4-pyrimidinyl){[(1.1-dimethylethyl)oxy]carbonyl}amino)benzoate

Chemical Property of ethyl 2-((2-chloro-5-methyl-4-pyrimidinyl){[(1.1-dimethylethyl)oxy]carbonyl}amino)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of ethyl 2-((2-chloro-5-methyl-4-pyrimidinyl){[(1.1-dimethylethyl)oxy]carbonyl}amino)benzoate

There total 1 articles about ethyl 2-((2-chloro-5-methyl-4-pyrimidinyl){[(1.1-dimethylethyl)oxy]carbonyl}amino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

ethyl 2-[(2-chloro-5-methyl-4-pyrimidinyl)amino]benzoate (325702-65-6) + di-tert-butyl dicarbonate (24424-99-5) → ethyl 2-((2-chloro-5-methyl-4-pyrimidinyl){[(1.1-dimethylethyl)oxy]carbonyl}amino)benzoate (1089653-99-5)

Guidance literature:

dimethylaminopyridine; In tetrahydrofuran; at 50 ℃; for 32h;

Reference yield: 58.0%

ethyl 2-((2-chloro-5-methyl-4-pyrimidinyl){[(1.1-dimethylethyl)oxy]carbonyl}amino)benzoate (1089653-99-5) + 6-(4-methyl-1-piperazinyl)-3-pyridinamine hydrochloride (1234971-67-5,82205-57-0) → ethyl 2-[{[(1,1-dimethylethyl)oxy]carbonyl}(5-methyl-2-{[6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino}-4-pyrimidinyl)amino]benzoate (1089654-00-1)

Guidance literature:

With caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 50 ℃; for 16.25h;

upstream raw materials:

ethyl 2-[(2-chloro-5-methyl-4-pyrimidinyl)amino]benzoate

di-tert-butyl dicarbonate

Downstream raw materials:

ethyl 2-[{[(1,1-dimethylethyl)oxy]carbonyl}(5-methyl-2-{[6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino}-4-pyrimidinyl)amino]benzoate