ethyl 2-[{[(1,1-dimethylethyl)oxy]carbonyl}(5-methyl-2-{[6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino}-4-pyrimidinyl)amino]benzoate

Base Information

• Chemical Name: ethyl 2-[{[(1,1-dimethylethyl)oxy]carbonyl}(5-methyl-2-{[6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino}-4-pyrimidinyl)amino]benzoate
• CAS No.: 1089654-00-1
• Molecular Formula: C₂₉H₃₇N₇O₄
• Molecular Weight: 547.657
• Mol file: 1089654-00-1.mol

Synonyms:ethyl 2-[{[(1,1-dimethylethyl)oxy]carbonyl}(5-methyl-2-{[6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino}-4-pyrimidinyl)amino]benzoate

Chemical Property of ethyl 2-[{[(1,1-dimethylethyl)oxy]carbonyl}(5-methyl-2-{[6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino}-4-pyrimidinyl)amino]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-[{[(1,1-dimethylethyl)oxy]carbonyl}(5-methyl-2-{[6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino}-4-pyrimidinyl)amino]benzoate

There total 1 articles about ethyl 2-[{[(1,1-dimethylethyl)oxy]carbonyl}(5-methyl-2-{[6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino}-4-pyrimidinyl)amino]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

ethyl 2-((2-chloro-5-methyl-4-pyrimidinyl){[(1.1-dimethylethyl)oxy]carbonyl}amino)benzoate (1089653-99-5) + 6-(4-methyl-1-piperazinyl)-3-pyridinamine hydrochloride (1234971-67-5,82205-57-0) → ethyl 2-[{[(1,1-dimethylethyl)oxy]carbonyl}(5-methyl-2-{[6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino}-4-pyrimidinyl)amino]benzoate (1089654-00-1)

Guidance literature:

With caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 50 ℃; for 16.25h;

Reference yield: 64.0%

ethyl 2-[{[(1,1-dimethylethyl)oxy]carbonyl}(5-methyl-2-{[6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino}-4-pyrimidinyl)amino]benzoate (1089654-00-1) + ethanolamine (141-43-5) → N-(2-hydroxyethyl)-2-[(5-methyl-2-{[6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino}-4-pyrimidinyl)amino]benzamide (1089653-74-6)

Guidance literature:

ethyl 2-[{[(1,1-dimethylethyl)oxy]carbonyl}(5-methyl-2-{[6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino}-4-pyrimidinyl)amino]benzoate; ethanolamine; at 80 - 85 ℃; for 44h;

With water; trifluoroacetic acid; In acetonitrile;

With sodium hydroxide; water; pH=12;

upstream raw materials:

ethyl 2-((2-chloro-5-methyl-4-pyrimidinyl){[(1.1-dimethylethyl)oxy]carbonyl}amino)benzoate

6-(4-methyl-1-piperazinyl)-3-pyridinamine hydrochloride

Downstream raw materials:

N-(2-hydroxyethyl)-2-[(5-methyl-2-{[6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino}-4-pyrimidinyl)amino]benzamide