N-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methyl)-3-phenyl-N-(thiophen-2-ylmethyl)propanamide

Base Information

Chemical Name:N-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methyl)-3-phenyl-N-(thiophen-2-ylmethyl)propanamide
CAS No.:1418131-49-3
Molecular Formula:C₂₂H₂₃N₃O₃S
Molecular Weight:409.509
Hs Code.:

Synonyms:N-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methyl)-3-phenyl-N-(thiophen-2-ylmethyl)propanamide

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Chemical Property of N-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methyl)-3-phenyl-N-(thiophen-2-ylmethyl)propanamide

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Technology Process of N-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methyl)-3-phenyl-N-(thiophen-2-ylmethyl)propanamide

There total 7 articles about N-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methyl)-3-phenyl-N-(thiophen-2-ylmethyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1418131-87-9
2-{[(thiophen-2-ylmethyl)-amino]-methyl}-3,5,7,8-tetrahydro-pyrano[4,3-d]pyrimidin-4-one

: 645-45-4
hydrocinnamic acid chloride

: 1418131-49-3
N-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methyl)-3-phenyl-N-(thiophen-2-ylmethyl)propanamide

Guidance literature:: With triethylamine; In dichloromethane; for 4h;

Reference yield:

: 127956-11-0
4-oxotetrahydro-2H-pyran-3-carboxylic acid methyl ester

: 1418131-49-3
N-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methyl)-3-phenyl-N-(thiophen-2-ylmethyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / methanol / 15 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

3: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 4 h

4: triethylamine / dichloromethane / 4 h

With palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; triethylamine; In methanol; dichloromethane;

Reference yield:

: 1418131-86-8
2-(aminomethyl)-7,8-dihydro-3H-pyrano[4,3-d]pyrimidin-4(5H)-one

: 1418131-49-3
N-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methyl)-3-phenyl-N-(thiophen-2-ylmethyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 4 h

2: triethylamine / dichloromethane / 4 h

With sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In dichloromethane;