17-(cyclopropylmethyl)-4,5α-epoxy-14β-[(2-methylbenzyl)oxy]-3-(triphenylmethoxy)morphinan-6-one ethane-1,2-diyl acetal

Base Information

Chemical Name:17-(cyclopropylmethyl)-4,5α-epoxy-14β-[(2-methylbenzyl)oxy]-3-(triphenylmethoxy)morphinan-6-one ethane-1,2-diyl acetal
CAS No.:646032-66-8
Molecular Formula:C₄₉H₄₉NO₅
Molecular Weight:731.932
Hs Code.:

Synonyms:17-(cyclopropylmethyl)-4,5α-epoxy-14β-[(2-methylbenzyl)oxy]-3-(triphenylmethoxy)morphinan-6-one ethane-1,2-diyl acetal

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Chemical Property of 17-(cyclopropylmethyl)-4,5α-epoxy-14β-[(2-methylbenzyl)oxy]-3-(triphenylmethoxy)morphinan-6-one ethane-1,2-diyl acetal

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Technology Process of 17-(cyclopropylmethyl)-4,5α-epoxy-14β-[(2-methylbenzyl)oxy]-3-(triphenylmethoxy)morphinan-6-one ethane-1,2-diyl acetal

There total 3 articles about 17-(cyclopropylmethyl)-4,5α-epoxy-14β-[(2-methylbenzyl)oxy]-3-(triphenylmethoxy)morphinan-6-one ethane-1,2-diyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 89-92-9
2-methylbenzyl bromide

: 633303-36-3
17-(cyclopropylmethyl)-4,5α-epoxy-14β-hydroxy-3-(triphenylmethoxy)morphinan-6-one ethane-1,2-diyl acetal

: 646032-66-8
17-(cyclopropylmethyl)-4,5α-epoxy-14β-[(2-methylbenzyl)oxy]-3-(triphenylmethoxy)morphinan-6-one ethane-1,2-diyl acetal

Guidance literature:: 17-(cyclopropylmethyl)-4,5α-epoxy-14β-hydroxy-3-(triphenylmethoxy)morphinan-6-one ethane-1,2-diyl acetal; With sodium hydride; In N,N-dimethyl-formamide; for 0.333333h; cooling;

2-methylbenzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 20h;
DOI:10.1002/hlca.200390187

Reference yield:

: 596-43-0
bromo-triphenyl-methane

: 646032-66-8
17-(cyclopropylmethyl)-4,5α-epoxy-14β-[(2-methylbenzyl)oxy]-3-(triphenylmethoxy)morphinan-6-one ethane-1,2-diyl acetal

Guidance literature:: Multi-step reaction with 2 steps

1.1: 85 percent / DMAP; Et₃N / CH₂Cl₂ / 24 h / Heating

2.1: NaH / dimethylformamide / 0.33 h / cooling

2.2: 13 percent / dimethylformamide / 20 h / 20 °C

With dmap; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200390187

Reference yield:

: 16676-32-7
(4'R,4a'S,7a'R,12b'S)-3'-(cyclopropylmethyl)-1',2',3',4',5',6'-hexahydro-4a'H,7a'H-spiro[[1,3]dioxolane-2,7'-[4,12]methanobenzofuro[3,2-e]isoquinoline]-4a',9'-diol

: 646032-66-8
17-(cyclopropylmethyl)-4,5α-epoxy-14β-[(2-methylbenzyl)oxy]-3-(triphenylmethoxy)morphinan-6-one ethane-1,2-diyl acetal

Guidance literature:: Multi-step reaction with 2 steps

1.1: 85 percent / DMAP; Et₃N / CH₂Cl₂ / 24 h / Heating

2.1: NaH / dimethylformamide / 0.33 h / cooling

2.2: 13 percent / dimethylformamide / 20 h / 20 °C

With dmap; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200390187