(1R,2R)-N-[cyano(2-methoxyphenyl)methyl]-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxamide

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Chemical Name:(1R,2R)-N-[cyano(2-methoxyphenyl)methyl]-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxamide
CAS No.:639792-05-5
Molecular Formula:C₂₇H₃₁FN₄O₃
Molecular Weight:478.567
Hs Code.:

Synonyms:(1R,2R)-N-[cyano(2-methoxyphenyl)methyl]-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxamide

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Chemical Property of (1R,2R)-N-[cyano(2-methoxyphenyl)methyl]-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxamide

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Technology Process of (1R,2R)-N-[cyano(2-methoxyphenyl)methyl]-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxamide

There total 4 articles about (1R,2R)-N-[cyano(2-methoxyphenyl)methyl]-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 639792-18-0
(+/-) 2-(2-methoxyphenyl) aminoacetonitrile hydrochloride

: 639792-12-4
(1R, 2R)-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxylic acid

: 639792-05-5
(1R,2R)-N-[cyano(2-methoxyphenyl)methyl]-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxamide

Guidance literature:: (+/-) 2-(2-methoxyphenyl) aminoacetonitrile hydrochloride; (1R, 2R)-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxylic acid; With O-(7-azabenzotriazol-1-yl)-N,N, N', N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h;

at 20 ℃; for 18h;

Reference yield:

: 96894-64-3
(1R,2R)-1,2-cyclohexanedicarboxylic acid monomethyl ester

: 639792-05-5
(1R,2R)-N-[cyano(2-methoxyphenyl)methyl]-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 18 h / 20 °C

2.1: sodium hydroxide / methanol; water / 24 h / 55 °C

3.1: O-(7-azabenzotriazol-1-yl)-N,N, N', N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

3.2: 18 h / 20 °C

With sodium hydroxide; O-(7-azabenzotriazol-1-yl)-N,N, N', N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water;

Reference yield:

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 639792-05-5
(1R,2R)-N-[cyano(2-methoxyphenyl)methyl]-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 18 h / 20 °C

2.1: sodium hydroxide / methanol; water / 24 h / 55 °C

3.1: O-(7-azabenzotriazol-1-yl)-N,N, N', N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

3.2: 18 h / 20 °C

With sodium hydroxide; O-(7-azabenzotriazol-1-yl)-N,N, N', N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water;