methyl (1R,2R)-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxylate

Base Information

Chemical Name:methyl (1R,2R)-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxylate
CAS No.:639792-11-3
Molecular Formula:C₁₉H₂₅FN₂O₃
Molecular Weight:348.418
Hs Code.:

Synonyms:methyl (1R,2R)-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxylate

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Chemical Property of methyl (1R,2R)-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxylate

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Technology Process of methyl (1R,2R)-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxylate

There total 1 articles about methyl (1R,2R)-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96894-64-3
(1R,2R)-1,2-cyclohexanedicarboxylic acid monomethyl ester

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 639792-11-3
methyl (1R,2R)-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxylate

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 18h;

Reference yield:

: 639792-11-3
methyl (1R,2R)-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxylate

: 639792-12-4
(1R, 2R)-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; water; at 55 ℃; for 24h;

Reference yield:

: 639792-11-3
methyl (1R,2R)-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxylate

: 639792-08-8
(1R,2R)-N-[(1S)-1-cyano-3-methoxypropyl]-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / methanol; water / 24 h / 55 °C

2.1: O-(7-azabenzotriazol-1-yl)-N,N, N', N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / 0 °C

2.2: 18 h / 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / 0.08 h / 0 °C

3.2: 0.08 h

3.3: 2 h / 0 °C

With sodium hydroxide; oxalyl dichloride; O-(7-azabenzotriazol-1-yl)-N,N, N', N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In 1-methyl-pyrrolidin-2-one; methanol; water;