N-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-7-yl)-4-nitrobenzamide

Base Information

Chemical Name:N-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-7-yl)-4-nitrobenzamide
CAS No.:1032373-49-1
Molecular Formula:C₂₉H₂₂N₄O₅
Molecular Weight:506.517
Hs Code.:

Synonyms:N-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-7-yl)-4-nitrobenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-7-yl)-4-nitrobenzamide

Chemical Property:

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Technology Process of N-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-7-yl)-4-nitrobenzamide

There total 2 articles about N-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-7-yl)-4-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1032373-46-8
7-amino-1,3-dibenzyl-1H-quinazoline-2,4-dione

: 122-04-3
4-nitro-benzoyl chloride

: 1032373-49-1
N-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-7-yl)-4-nitrobenzamide

Guidance literature:: 7-amino-1,3-dibenzyl-1H-quinazoline-2,4-dione; With lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; at -78 ℃; for 2h; Inert atmosphere;

4-nitro-benzoyl chloride; In tetrahydrofuran; diethyl ether; at -78 - 50 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2008.09.058

Reference yield:

: 1032373-48-0
6-amino-1,3-dibenzyl-1H-quinazoline-2,4-dione

: 1032373-46-8
7-amino-1,3-dibenzyl-1H-quinazoline-2,4-dione

: 122-04-3
4-nitro-benzoyl chloride

: 1032373-49-1
N-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-7-yl)-4-nitrobenzamide

: 1032373-50-4
N-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)-4-nitrobenzamide

Guidance literature:: 6-amino-1,3-dibenzyl-1H-quinazoline-2,4-dione; 7-amino-1,3-dibenzyl-1H-quinazoline-2,4-dione; With lithium diisopropyl amide; In tetrahydrofuran;

4-nitro-benzoyl chloride; In tetrahydrofuran; at -78 - 50 ℃;

Reference yield: 80.0%

: 1032373-49-1
N-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-7-yl)-4-nitrobenzamide

: 1032373-51-5
4-amino-N-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-7-yl)benzamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; for 2h; under 1810.07 Torr;
DOI:10.1016/j.bmc.2008.09.058