4-(1-(2-hydroxyethyl)-6-(butylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-methylbenzenesulfonamide

Base Information

Chemical Name:4-(1-(2-hydroxyethyl)-6-(butylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-methylbenzenesulfonamide
CAS No.:1350549-22-2
Molecular Formula:C₁₈H₂₄N₆O₃S
Molecular Weight:404.493
Hs Code.:

Synonyms:4-(1-(2-hydroxyethyl)-6-(butylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-methylbenzenesulfonamide

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Chemical Property of 4-(1-(2-hydroxyethyl)-6-(butylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-methylbenzenesulfonamide

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Technology Process of 4-(1-(2-hydroxyethyl)-6-(butylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-methylbenzenesulfonamide

There total 4 articles about 4-(1-(2-hydroxyethyl)-6-(butylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₁H₁₆BrN₅O

: 226396-31-2
(4-[N-methylsulfamoyl]phenyl)boronic acid

: 1350549-22-2
4-(1-(2-hydroxyethyl)-6-(butylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-methylbenzenesulfonamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; at 20 - 150 ℃; for 0.266667h; Microwave irradiation;
DOI:10.1016/j.ejmech.2013.03.035

Reference yield:

: 1350550-51-4
3-bromo-N-butyl-1H-pyrazolo[3,4-d]pyrimidin-6-amine

: 1350549-22-2
4-(1-(2-hydroxyethyl)-6-(butylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 150 °C / Microwave irradiation

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 0.27 h / 20 - 150 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2013.03.035

Reference yield:

: 1306829-95-7
3-bromo-6-(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidine

: 1350549-22-2
4-(1-(2-hydroxyethyl)-6-(butylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran / 2 h / 20 °C

1.2: 2 h / 0 - 60 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 150 °C / Microwave irradiation

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 0.27 h / 20 - 150 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide; 3.1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2013.03.035