1306829-95-7

Basic information

• Product Name: 3-BroMo-6-(Methylthio)-1H-pyrazolo[3,4-d]pyriMidine
• Synonyms: 3-BroMo-6-(Methylthio)-1H-pyrazolo[3,4-d]pyriMidine;3-BroMo-6-(Methylthio)-1H...;3-bromo-6-(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidine;3-BROMO-6-(METHYLTHIO)-1H-PYRAZOLO[3,4-D]PYRIMIDIN
• CAS NO: 1306829-95-7
• Molecular Formula: C₆H₅BrN₄S
• Molecular Weight: 245.0997
• Mol File: 1306829-95-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3-BroMo-6-(Methylthio)-1H-pyrazolo[3,4-d]pyriMidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BroMo-6-(Methylthio)-1H-pyrazolo[3,4-d]pyriMidine(1306829-95-7)
• EPA Substance Registry System: 3-BroMo-6-(Methylthio)-1H-pyrazolo[3,4-d]pyriMidine(1306829-95-7)

Safety Data

• Hazardous Substances Data: 1306829-95-7(Hazardous Substances Data)

Usage

General Description

3-Bromo-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine is a chemical compound with the molecular formula C7H6BrN3S. It is a pyrazolopyrimidine derivative with a bromo and methylthio substituent. This chemical is used in the pharmaceutical industry for the development of potential drug candidates, particularly in the field of anti-cancer and anti-inflammatory drugs. It is also used as a building block in organic synthesis and medicinal chemistry. The compound's structure and properties make it an important intermediate for the synthesis of various biologically active compounds.

Upstream product

• 117147-06-5 ethyl 4-hydrazinyl-2-(methylsulfanyl)pyrimidine-5-carboxylate 
• 100047-42-5 6-(methylsulfanyl)-1H,2H,3H-pyrazolo[3,4-d]pyrimidin-3-one 
• 5909-24-0 4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester 

Downstream Products

• 1306830-00-1 1-cyclohexyl-3-phenyl-N-propyl-1H-pyrazolo[3,4-d]pyrimidin-6-amine 
• 1306830-05-6 tert-butyl 4-((3-(2-methoxyphenyl)-6-(propylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)piperidine-1-carboxylate 
• 1306830-06-7 C₂₁H₂₈N₆O 
• 1306830-08-9 C₂₂H₂₀N₆ 
• 1306830-10-3 1-isopropyl-3-phenyl-N-propyl-1H-pyrazolo[3,4-d]pyrimidin-6-amine 
• 1306830-11-4 C₁₈H₂₁N₅ 
• 1306830-12-5 C₁₆H₁₉N₅ 
• 1306830-13-6 C₁₉H₁₉N₅O 
• 1306830-14-7 1-isopropyl-N,3-diphenyl-1H-pyrazolo[3,4-d]pyrimidin-6-amine 
• 1306830-15-8 C₂₁H₂₁N₅O 
• 1306830-16-9 C₂₀H₁₈FN₅ 
• 1306830-17-0 6-(3-chloropropoxy)-1-isopropyl-3-phenyl-1H-pyrazolo[3,4-d]pyrimidine 
• 1306830-18-1 C₁₈H₂₂N₄O 
• 1306830-19-2 C₂₀H₂₄N₄O 

Relevant articles and documents

MERTK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

ALKYNYL ALCOHOLS AND METHODS OF USE

The invention relates to compounds of Formula (0): wherein Q, A1-A8, R4 and R5 and each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over- activation of NF-kB signaling is observed.

Microwave-assisted, divergent solution-phase synthesis of 1,3,6-trisubstituted pyrazolo[3,4- d ]pyrimidines

A concise and highly divergent synthetic route has been developed to rapidly access 1,3,6-trisubstituted pyrazolopyrimidines. The synthesis features a microwave assisted one-pot N1-alkylation/Suzuki-Miyaura reaction as the key step. The sequence of the synthetic scheme can be varied to selectively modify the N1, C3, or C6 position at a late synthetic stage, thereby providing a highly efficient approach to explore the structure-activity relationships of pyrazolopyrimidine derivatives. The scope of these reactions has also been explored.