1306829-95-7

Usage

Uses

Used in Pharmaceutical Industry:
3-Bromo-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine is used as a potential drug candidate for the development of anti-cancer and anti-inflammatory drugs. Its unique structure and properties make it a promising candidate for the treatment of various diseases.
Used in Organic Synthesis:
3-Bromo-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine is used as a building block in organic synthesis, allowing for the creation of new compounds with potential applications in various fields.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 3-Bromo-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine is utilized as an important intermediate for the synthesis of biologically active compounds. Its unique structure and properties enable the development of novel therapeutic agents with potential applications in treating various medical conditions.

Upstream product

• 5909-24-0 4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester 
• 100047-42-5 6-(methylsulfanyl)-1H,2H,3H-pyrazolo[3,4-d]pyrimidin-3-one 
• 117147-06-5 ethyl 4-hydrazinyl-2-(methylsulfanyl)pyrimidine-5-carboxylate 

Downstream Products

• 1306830-00-1 1-cyclohexyl-3-phenyl-N-propyl-1H-pyrazolo[3,4-d]pyrimidin-6-amine 
• 1306830-05-6 tert-butyl 4-((3-(2-methoxyphenyl)-6-(propylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)piperidine-1-carboxylate 
• 1306830-06-7 C₂₁H₂₈N₆O 
• 1306830-08-9 C₂₂H₂₀N₆ 
• 1306830-10-3 1-isopropyl-3-phenyl-N-propyl-1H-pyrazolo[3,4-d]pyrimidin-6-amine 
• 1306830-11-4 C₁₈H₂₁N₅ 
• 1306830-12-5 C₁₆H₁₉N₅ 
• 1306830-13-6 C₁₉H₁₉N₅O 
• 1306830-14-7 1-isopropyl-N,3-diphenyl-1H-pyrazolo[3,4-d]pyrimidin-6-amine 
• 1306830-15-8 C₂₁H₂₁N₅O 
• 1306830-16-9 C₂₀H₁₈FN₅ 
• 1306830-17-0 6-(3-chloropropoxy)-1-isopropyl-3-phenyl-1H-pyrazolo[3,4-d]pyrimidine 
• 1306830-18-1 C₁₈H₂₂N₄O 
• 1306830-19-2 C₂₀H₂₄N₄O 

Relevant academic research and scientific papers

MERTK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

PHENOXYMETHYL DERIVATIVES

The invention provides novel compounds having the general formula (I), wherein RA, RB, RC, RC1 and W are as defined herein, compositions including the compounds and methods of using the compounds.

ALKYNYL ALCOHOLS AND METHODS OF USE

The invention relates to compounds of Formula (0): wherein Q, A1-A8, R4 and R5 and each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over- activation of NF-kB signaling is observed.

Discovery of small molecule Mer kinase inhibitors for the treatment of pediatric acute lymphoblastic leukemia

Ectopic Mer expression promotes pro-survival signaling and contributes to leukemogenesis and chemoresistance in childhood acute lymphoblastic leukemia (ALL). Consequently, Mer kinase inhibitors may promote leukemic cell death and further act as chemosensitizers increasing efficacy and reducing toxicities of current ALL regimens. We have applied a structure-based design approach to discover novel small molecule Mer kinase inhibitors. Several pyrazolopyrimidine derivatives effectively inhibit Mer kinase activity at subnanomolar concentrations. Furthermore, the lead compound shows a promising selectivity profile against a panel of 72 kinases and has excellent pharmacokinetic properties. We also describe the crystal structure of the complex between the lead compound and Mer, opening new opportunities for further optimization and new template design.

PYRAZOLOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER

Compound of Formula (I): are described, along with pharmaceutically acceptable salts thereof, compositions containing the same, and methods of use thereof in the treatment of cancer.

Microwave-assisted, divergent solution-phase synthesis of 1,3,6-trisubstituted pyrazolo[3,4- d ]pyrimidines

A concise and highly divergent synthetic route has been developed to rapidly access 1,3,6-trisubstituted pyrazolopyrimidines. The synthesis features a microwave assisted one-pot N1-alkylation/Suzuki-Miyaura reaction as the key step. The sequence of the synthetic scheme can be varied to selectively modify the N1, C3, or C6 position at a late synthetic stage, thereby providing a highly efficient approach to explore the structure-activity relationships of pyrazolopyrimidine derivatives. The scope of these reactions has also been explored.