(2R,3R)-1-tert-Butoxycarbonylamino-2,3-diphenyl-cyclopropanecarboxylic acid ethyl ester

Base Information

Chemical Name:(2R,3R)-1-tert-Butoxycarbonylamino-2,3-diphenyl-cyclopropanecarboxylic acid ethyl ester
CAS No.:1033722-44-9
Molecular Formula:C₂₃H₂₇NO₄
Molecular Weight:381.472
Hs Code.:

Synonyms:(2R,3R)-1-tert-Butoxycarbonylamino-2,3-diphenyl-cyclopropanecarboxylic acid ethyl ester

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Chemical Property of (2R,3R)-1-tert-Butoxycarbonylamino-2,3-diphenyl-cyclopropanecarboxylic acid ethyl ester

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Technology Process of (2R,3R)-1-tert-Butoxycarbonylamino-2,3-diphenyl-cyclopropanecarboxylic acid ethyl ester

There total 5 articles about (2R,3R)-1-tert-Butoxycarbonylamino-2,3-diphenyl-cyclopropanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 214492-24-7
(2R,3R)-1-(ethoxycarbonyl)-2,3-diphenylcyclopropane-1-carboxylic acid

: 75-65-0
tert-butyl alcohol

: 1033722-44-9
(2R,3R)-1-tert-Butoxycarbonylamino-2,3-diphenyl-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; for 15h; Heating;
DOI:10.1021/ja981153d

Reference yield:

: 183184-04-5
(R,R)-(+)-4,5-diphenyl-1,3,2-dioxathiolan-2-one

: 1033722-44-9
(2R,3R)-1-tert-Butoxycarbonylamino-2,3-diphenyl-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaIO₄, RuCl₃ / CCl₄; acetonitrile / 1 h / Ambient temperature

2: 1.) NaH / 1.) DME, 2.) DME, RT, 2 h

3: aq. NaIO₄, RuCl₃ / acetonitrile; chlorosulfonic acid / 15 h / Ambient temperature

4: 55 percent / diphenylphosphoryl azide, Et₃N / 15 h / Heating

With ruthenium trichloride; sodium periodate; diphenylphosphoranyl azide; sodium hydride; triethylamine; In tetrachloromethane; chlorosulfonic acid; acetonitrile;
DOI:10.1021/ja981153d

Reference yield:

: 52340-78-0
(R,R)-hydroxybenzoin

: 1033722-44-9
(2R,3R)-1-tert-Butoxycarbonylamino-2,3-diphenyl-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂ / CCl₄ / 0.5 h / Heating

2: aq. NaIO₄, RuCl₃ / CCl₄; acetonitrile / 1 h / Ambient temperature

3: 1.) NaH / 1.) DME, 2.) DME, RT, 2 h

4: aq. NaIO₄, RuCl₃ / acetonitrile; chlorosulfonic acid / 15 h / Ambient temperature

5: 55 percent / diphenylphosphoryl azide, Et₃N / 15 h / Heating

With ruthenium trichloride; sodium periodate; thionyl chloride; diphenylphosphoranyl azide; sodium hydride; triethylamine; In tetrachloromethane; chlorosulfonic acid; acetonitrile;
DOI:10.1021/ja981153d