(Z)-3-Iodo-3-(toluene-4-sulfonyl)-acrylic acid (S)-2,4,4-trimethyl-3-vinyl-cyclohex-2-enyl ester

Base Information

Chemical Name:(Z)-3-Iodo-3-(toluene-4-sulfonyl)-acrylic acid (S)-2,4,4-trimethyl-3-vinyl-cyclohex-2-enyl ester
CAS No.:123218-26-8
Molecular Formula:C₂₁H₂₅IO₄S
Molecular Weight:500.398
Hs Code.:

Synonyms:(Z)-3-Iodo-3-(toluene-4-sulfonyl)-acrylic acid (S)-2,4,4-trimethyl-3-vinyl-cyclohex-2-enyl ester

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Chemical Property of (Z)-3-Iodo-3-(toluene-4-sulfonyl)-acrylic acid (S)-2,4,4-trimethyl-3-vinyl-cyclohex-2-enyl ester

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Technology Process of (Z)-3-Iodo-3-(toluene-4-sulfonyl)-acrylic acid (S)-2,4,4-trimethyl-3-vinyl-cyclohex-2-enyl ester

There total 2 articles about (Z)-3-Iodo-3-(toluene-4-sulfonyl)-acrylic acid (S)-2,4,4-trimethyl-3-vinyl-cyclohex-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13894-21-8
ethynyl p-tolyl sulfone

: 123218-26-8
(Z)-3-Iodo-3-(toluene-4-sulfonyl)-acrylic acid (S)-2,4,4-trimethyl-3-vinyl-cyclohex-2-enyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) hexane, THF, 90 min, -90 deg C - -100 deg C, 2.) -95 deg C to 0 deg C, 45 min

2: 1.) Ph₃P*I₂, 2.) 2,6-di tert-butyl-4-methylpyridine / 1.) CH₂Cl₂, -35 deg C, 30 min, 2.) -35 deg C to 23 deg C over 2 h

With n-butyllithium; 2,6-di-tert-butyl-4-methylpyridine; triphenylphospine diiodide;
DOI:10.1016/S0040-4039(00)82359-X

Reference yield:

: 114250-62-3
3-(p-toluenesulfonyl)propiolic acid

: 97760-29-7
(S)-(-)-2,4,4-trimethyl-3-vinyl-2-cyclohexen-1-ol

: 123218-26-8
(Z)-3-Iodo-3-(toluene-4-sulfonyl)-acrylic acid (S)-2,4,4-trimethyl-3-vinyl-cyclohex-2-enyl ester

Guidance literature:: With 2,6-di-tert-butyl-4-methylpyridine; triphenylphospine diiodide; Yield given. Multistep reaction; 1.) CH₂Cl₂, -35 deg C, 30 min, 2.) -35 deg C to 23 deg C over 2 h;
DOI:10.1016/S0040-4039(00)82359-X