97760-29-7

Upstream product

• 114298-66-7 2,4,4-trimethyl-3-vinyl-cyclohex-2-enol 
• 60078-92-4 2,4,4-trimethyl-3-formyl-2-cyclohexen-1-ol 
• 127-41-3 alpha-ionone 
• 190059-33-7 (E)-4-(1,3,3-Trimethyl-7-oxa-bicyclo[4.1.0]hept-2-yl)-but-3-en-2-one 
• 85679-49-8 2,4,4-trimethyl-3-vinyl-cyclohex-2-enone 

Downstream Products

• 123218-26-8 (Z)-3-Iodo-3-(toluene-4-sulfonyl)-acrylic acid (S)-2,4,4-trimethyl-3-vinyl-cyclohex-2-enyl ester 
• 114250-63-4 (8aR,8bR)-6,6,8b-Trimethyl-3-(toluene-4-sulfonyl)-4,6,7,8,8a,8b-hexahydro-naphtho[1,8-bc]furan-2-one 
• 133397-57-6 (S)-(-)-1-(2-propynyloxy)-2,4,4-trimethyl-3-vinyl-2-cyclohexene 
• 769122-49-8 (1R,4aR,6aR,12R,12aR,12bS)-1-acetoxy-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-4a,12,12a-trihydroxy-4,4,6a,12b-tetramethyl-9-(3',4'-dimethoxyphenyl)-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-11-one 
• 769122-56-7 (1R,4aR,6aR,12R,12aR,12bS)-1-acetoxy-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-4a,12,12a-trihydroxy-4,4,6a,12b-tetramethyl-9-(4'-methoxyphenyl)-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-11-one 
• 769122-52-3 (1R,4aR,6aR,12aR,12bS)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-1,4a,12a-trihydroxy-4,4,6a,12b-tetramethyl-9-(3',4'-dimethoxyphenyl)-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-11-one 
• 769126-98-9 (4aR,6aR,12aR,12bS)-3,4,4a,5,6,6a,12,12a,12b-nonahydro-4a,12a-dihydroxy-4,4,6a,12b-tetramethyl-9-(3',4'-dimethoxyphenyl)-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-1,11(3H)-dione 
• 769122-58-9 (1R,4aR,6aR,12aR,12bS)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-1,4a,12a-trihydroxy-4,4,6a,12b-tetramethyl-9-(4'-methoxyphenyl)-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-11-one 
• 346688-04-8 1,3,4,4a,5,6,6a,12b-octahydro-4aα,5α-epoxy-1α-hydroxy-4,4,6aβ,12bβ-tetramethyl-9-(3',4'-dimethoxyphenyl)-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-11-one 
• 346688-16-2 (4aR,6aR,12bS)-3,4,4a,5,6,6a,12b-heptahydro-4a-hydroxy-4,4,6a,12b-tetramethyl-9-(3',4'-dimethoxyphenyl)-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-1,11(3H)-dione 
• 346688-14-0 (1S,4aR,6aR,12bS)-1,3,4,4a,5,6,6a,12b-octahydro-1,4a-dihydroxy-4,4,6a,12b-tetramethyl-9-(3',4'-dimethoxyphenyl)-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-11-one 
• 769122-48-7 (1R,4aR,6aR,12bS)-1,3,4,4a,5,6,6a,12b-octahydro-1,4a-dihydroxy-4,4,6a,12b-tetramethyl-9-(3',4'-dimethoxyphenyl)-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-11-one 
• 769122-54-5 (1S,4aR,6aR,12bS)-1,3,4,4a,5,6,6a,12b-octahydro-1,4a-dihydroxy-4,4,6a,12b-tetramethyl-9-(4'-methoxyphenyl)-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-11-one 
• 769122-55-6 (1R,4aR,6aR,12bS)-1,3,4,4a,5,6,6a,12b-octahydro-1,4a-dihydroxy-4,4,6a,12b-tetramethyl-9-(4'-methoxyphenyl)-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-11-one 

Relevant academic research and scientific papers

Enantioselective synthesis of 1-(R)-hydroxypolygodial and its 9α epimer, 1-(R)-hydroxyisotadeonal

The enantioselective synthesis of 1-(R)-hydroxypolygodial and its epimer at C-9 is described. α-Ionone was the starting material. Key steps of these syntheses included a Corey-Bakshi-Shibata oxazaborolidine-mediated reduction and a stereoselective Diels-A

Enantioselective synthesis of 1(R)-hydroxypolygodial

Enantioselective preparation of 1(R)-hydroxypolygodial (5) has been achieved starting from α-ionone through a synthetic strategy involving a Corey-Bakshi-Shibata oxazaborolidine-mediated reduction and a stereoselective Diels-Alder reaction as key steps.

Absolute stereochemistries and total synthesis of (+)-arisugacins a and B, potent, orally bioactive and selective inhibitors of acetylcholinesterase

In the current studies, we used the Kakisawa-Kashman modification of the Mosher NMR method to determine the complete absolute stereochemistry of arisugacins. We also report the convergent total synthesis of (+)-arisugacins A and B by a sequence including

Total synthesis of forskolin - Part III studies related to an asymmetric synthesis

A modification of the Corey CBS methodology for the asymmetric reduction of the dienone 3A affords the dienol 4A with an ee = 98% (92% yield). The intramolecular Diels-Alder reaction of the derived tetrolate 7 yields the tricyclic la

Microbial synthesis of optically pure (R)-2,4,4-trimethyl-3-(2'-hydroxyethyl)-cyclohex-2-en-1-ol, a new and versatile chiral building block for terpene synthesis

The hydroxylation of 2,4,4-trimethyl-3-(2'-hydroxyethyl)-2-cyclohexene by Mucor plumbeus, after usual work up and a subsequent single crystallization, gave the corresponding optically pure (1R)-hydroxy synthon.