N-(5-hydroxyadamantane-2-yl)-2-(4-(2-hydroxypropane-2-yl)phenylsulfonamido)-2-methylpropanamide

Base Information

Chemical Name:N-(5-hydroxyadamantane-2-yl)-2-(4-(2-hydroxypropane-2-yl)phenylsulfonamido)-2-methylpropanamide
CAS No.:1422026-80-9
Molecular Formula:C₂₃H₃₄N₂O₅S
Molecular Weight:450.599
Hs Code.:

Synonyms:N-(5-hydroxyadamantane-2-yl)-2-(4-(2-hydroxypropane-2-yl)phenylsulfonamido)-2-methylpropanamide

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Chemical Property of N-(5-hydroxyadamantane-2-yl)-2-(4-(2-hydroxypropane-2-yl)phenylsulfonamido)-2-methylpropanamide

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Technology Process of N-(5-hydroxyadamantane-2-yl)-2-(4-(2-hydroxypropane-2-yl)phenylsulfonamido)-2-methylpropanamide

There total 3 articles about N-(5-hydroxyadamantane-2-yl)-2-(4-(2-hydroxypropane-2-yl)phenylsulfonamido)-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1422027-95-9
2-(4-acetylphenylsulfonamido)-N-(5-hydroxyadamantane-2-yl)-2-methylpropanamide

: 75-16-1
methylmagnesium bromide

: 1422026-80-9
N-(5-hydroxyadamantane-2-yl)-2-(4-(2-hydroxypropane-2-yl)phenylsulfonamido)-2-methylpropanamide

Guidance literature:: In tetrahydrofuran; toluene; for 6h; Cooling with ice;

Reference yield:

: 1308111-74-1
methyl 2-(4-acetylphenylsulfonamido)-2-methylpropanoate

: 1422026-80-9
N-(5-hydroxyadamantane-2-yl)-2-(4-(2-hydroxypropane-2-yl)phenylsulfonamido)-2-methylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 12 h / 20 °C

1.2: pH 2 - 3

2.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 12 h / 20 °C

3.1: tetrahydrofuran; toluene / 6 h / Cooling with ice

With lithium hydroxide monohydrate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; toluene;

Reference yield:

: 809240-68-4
2-(4-acetylbenzenesulfonylamino)-2-methylpropionic acid

: 75375-89-2,62058-13-3
4-aminoadamantan-1-ol

: 1422026-80-9
N-(5-hydroxyadamantane-2-yl)-2-(4-(2-hydroxypropane-2-yl)phenylsulfonamido)-2-methylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 12 h / 20 °C

2: tetrahydrofuran; toluene / 6 h / Cooling with ice

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; toluene;