N-<2-(methylethyl)-1,4-dioxo-4-<(phenylmethoxy)amino>butyl>-β-alanine 1,1-dimethylethyl ester

Base Information

Chemical Name:N-<2-(methylethyl)-1,4-dioxo-4-<(phenylmethoxy)amino>butyl>-β-alanine 1,1-dimethylethyl ester
CAS No.:164364-60-7
Molecular Formula:C₂₁H₃₂N₂O₅
Molecular Weight:392.495
Hs Code.:

Synonyms:N-<2-(methylethyl)-1,4-dioxo-4-<(phenylmethoxy)amino>butyl>-β-alanine 1,1-dimethylethyl ester

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Chemical Property of N-<2-(methylethyl)-1,4-dioxo-4-<(phenylmethoxy)amino>butyl>-β-alanine 1,1-dimethylethyl ester

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Technology Process of N-<2-(methylethyl)-1,4-dioxo-4-<(phenylmethoxy)amino>butyl>-β-alanine 1,1-dimethylethyl ester

There total 5 articles about N-<2-(methylethyl)-1,4-dioxo-4-<(phenylmethoxy)amino>butyl>-β-alanine 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 622-33-3
N-benzyloxyamine

: 164364-53-8
N-<4-hydroxy-2-(methylethyl)-1,4-dioxobutyl>-β-alanine 1,1-dimethylethyl ester

: 164364-60-7
N-<2-(methylethyl)-1,4-dioxo-4-<(phenylmethoxy)amino>butyl>-β-alanine 1,1-dimethylethyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 41h;
DOI:10.1021/jm00012a011

Reference yield:

: 584-27-0
2-isopropylidenesuccinic acid

: 164364-60-7
N-<2-(methylethyl)-1,4-dioxo-4-<(phenylmethoxy)amino>butyl>-β-alanine 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / acetyl chloride / 0.33 h / Heating

2: 69 percent / CHCl₃ / 72 h / Heating

3: 100 percent / iPr₂NEt, HOBt-H₂O, DCC / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) 20 deg C, 46 h

4: 1.) H₂, 2.) H₂ / 1.) 10percent Pd/C, 2.) PtO₂ / 1.) methanol, 40 psi, 13 h, 2.) methanol, 23 h

5: 43 percent / DCC / dimethylformamide / 41 h / 20 °C

With hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; acetyl chloride; dicyclohexyl-carbodiimide; platinum(IV) oxide; palladium on activated charcoal; In dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00012a011

Reference yield:

: 130165-83-2
3-(methoxycarbonyl)-4-methylpent-3-enoic acid

: 164364-60-7
N-<2-(methylethyl)-1,4-dioxo-4-<(phenylmethoxy)amino>butyl>-β-alanine 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: NaOH / H₂O / 12 h

2: 97 percent / acetyl chloride / 0.33 h / Heating

3: 69 percent / CHCl₃ / 72 h / Heating

4: 100 percent / iPr₂NEt, HOBt-H₂O, DCC / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) 20 deg C, 46 h

5: 1.) H₂, 2.) H₂ / 1.) 10percent Pd/C, 2.) PtO₂ / 1.) methanol, 40 psi, 13 h, 2.) methanol, 23 h

6: 43 percent / DCC / dimethylformamide / 41 h / 20 °C

With sodium hydroxide; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; acetyl chloride; dicyclohexyl-carbodiimide; platinum(IV) oxide; palladium on activated charcoal; In dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00012a011