N-(3-(2-bromo-4-fluoro-5-(3-phenylureido)phenyl)-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)-2-cyanoacetamide

Base Information

Chemical Name:N-(3-(2-bromo-4-fluoro-5-(3-phenylureido)phenyl)-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)-2-cyanoacetamide
CAS No.:1442473-40-6
Molecular Formula:C₂₆H₂₀BrFN₆O₃
Molecular Weight:563.386
Hs Code.:

Synonyms:N-(3-(2-bromo-4-fluoro-5-(3-phenylureido)phenyl)-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)-2-cyanoacetamide

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Chemical Property of N-(3-(2-bromo-4-fluoro-5-(3-phenylureido)phenyl)-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)-2-cyanoacetamide

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Technology Process of N-(3-(2-bromo-4-fluoro-5-(3-phenylureido)phenyl)-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)-2-cyanoacetamide

There total 10 articles about N-(3-(2-bromo-4-fluoro-5-(3-phenylureido)phenyl)-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)-2-cyanoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1442473-09-7
1-(5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-bromo-2-fluorophenyl)-3- phenylurea

: 105-56-6
ethyl 2-cyanoacetate

: 1442473-40-6
N-(3-(2-bromo-4-fluoro-5-(3-phenylureido)phenyl)-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)-2-cyanoacetamide

Guidance literature:: 1-(5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-bromo-2-fluorophenyl)-3- phenylurea; ethyl 2-cyanoacetate; at 105 - 125 ℃; for 52.5h;

With 1-Methylpyrrolidine; at 125 ℃; for 5h;

Reference yield:

: 61150-59-2
2-(2-bromo-4-fluorophenyl)acetic acid

: 1442473-40-6
N-(3-(2-bromo-4-fluoro-5-(3-phenylureido)phenyl)-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)-2-cyanoacetamide

Guidance literature:: Multi-step reaction with 8 steps

1: nitric acid / ethyl acetate / 0.25 h / -15 - 5 °C

2: sulfuric acid / 85 °C

3: iron; ammonium chloride / ethanol / 1 h / 55 °C

4: potassium fluoride; aluminum oxide / N,N-dimethyl acetamide / 2 h / Sonication

5: 140 °C

6: trifluoroacetic acid / trifluoroacetic acid; ethyl acetate / 48 h / 50 - 60 °C

7: triethylamine / dichloromethane / 72 h / 20 °C

8: 52.5 h / 105 - 125 °C

With aluminum oxide; potassium fluoride; sulfuric acid; nitric acid; iron; ammonium chloride; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl acetamide; ethyl acetate; trifluoroacetic acid;

Reference yield:

: 1442471-26-2
ethyl 2-(5-amino-2-bromo-4-fluorophenyl)acetate

: 1442473-40-6
N-(3-(2-bromo-4-fluoro-5-(3-phenylureido)phenyl)-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)-2-cyanoacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium fluoride; aluminum oxide / N,N-dimethyl acetamide / 2 h / Sonication

2: 140 °C

3: trifluoroacetic acid / trifluoroacetic acid; ethyl acetate / 48 h / 50 - 60 °C

4: triethylamine / dichloromethane / 72 h / 20 °C

5: 52.5 h / 105 - 125 °C

With aluminum oxide; potassium fluoride; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl acetamide; ethyl acetate; trifluoroacetic acid;