61150-59-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-4-fluorophenylacetic acid is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure, featuring a bromine and fluorine atom, allows for the creation of new compounds with potential therapeutic applications.
Used in Agrochemical Industry:
2-Bromo-4-fluorophenylacetic acid is used as a building block in the development of agrochemicals. Its chemical properties can be utilized to create new compounds that can be used in the production of pesticides, herbicides, and other agricultural products.
Used in Organic Chemistry Research:
2-Bromo-4-fluorophenylacetic acid is used as a research compound in organic chemistry. Its distinct structure and reactivity make it a valuable tool for studying chemical reactions and exploring new synthetic pathways.

InChI:InChI=1/C8H6BrFO2/c9-7-4-6(10)2-1-5(7)3-8(11)12/h1-2,4H,3H2,(H,11,12)

Upstream product

• 61150-57-0 2-bromo-4-fluorobenzyl bromide 
• 1422-53-3 2-bromo-4-fluorotoluene 
• 61150-58-1 2-(2-bromo-4-fluorophenyl)acetonitrile 

Downstream Products

• 65999-41-9 2-(2-bromo-4-fluorophenyl)acetamide 
• 61150-66-1 2-(4-chloro-3-methoxyphenylthio)-4-fluorophenylacetic acid 
• 1086601-89-9 (2-bromo-4-fluoro-phenyl)-acetyl chloride 
• 1450904-10-5 2-bromo-N-(2-bromo-4,6-difluorophenyl)-4-fluorobenzeneethanethioamide 
• 1450904-09-2 2-bromo-N-(2-bromo-4,6-difluorophenyl)-4-fluorobenzeneacetamide 

Relevant academic research and scientific papers

Chiral Magnesium Bisphosphate-Catalyzed Asymmetric Double C(sp3)-H Bond Functionalization Based on Sequential Hydride Shift/Cyclization Process

Described herein is a chiral magnesium bisphosphate-catalyzed asymmetric double C(sp3)-H bond functionalization triggered by a sequential hydride shift/cyclization process. This reaction consists of stereoselective domino C(sp3)-H bond functionalization: (1) a highly enantio- and diastereoselective C(sp3)-H bond functionalization by chiral magnesium bisphosphate (first [1,5]-hydride shift), and (2) a highly diastereoselective C(sp3)-H bond functionalization by an achiral catalyst (Yb(OTf)3, second [1,5]-hydride shift).

Highly diastereoselective synthesis of tetralin-fused spirooxindoles via lewis acid-catalyzed C(sp3)H bond functionalization

A highly diastereoselective synthesis of tetralin-fused spirooxindole derivatives was described. Treatment of benzylidene oxindoles with a catalytic amount of Sc(OTf)3 in refluxing hexane afforded the target compounds in good chemical yields with excellent diastereoselectivities (up to >20:1). Detailed investigation of the reaction mechanism revealed that both interconversion of the two diastereomers and their solubility difference in reaction medium were the key to achieving excellent diastereoselectivities.

Synthesis of N-alkoxyindol-2-ones by copper-catalyzed intramolecular N-arylation of hydroxamates

The first example of copper-catalyzed intramolecular N-arylation of hydroxamic acid derivatives is presented. Based on this transformation a new method for the synthesis of N-alkoxyindol-2-ones from 2-(2-bromoaryl) acetylhydroxamates has been developed. T