(1S,3R,4S,5R)-5-(2-Benzyloxy-ethyl)-1-(tert-butyl-dimethyl-silanyloxy)-1-cyclohexyl-3,7-dimethyl-4-triethylsilanyloxy-oct-7-en-2-one

Base Information

Chemical Name:(1S,3R,4S,5R)-5-(2-Benzyloxy-ethyl)-1-(tert-butyl-dimethyl-silanyloxy)-1-cyclohexyl-3,7-dimethyl-4-triethylsilanyloxy-oct-7-en-2-one
CAS No.:83005-61-2
Molecular Formula:C₃₇H₆₆O₄Si₂
Molecular Weight:631.1
Hs Code.:

Synonyms:(1S,3R,4S,5R)-5-(2-Benzyloxy-ethyl)-1-(tert-butyl-dimethyl-silanyloxy)-1-cyclohexyl-3,7-dimethyl-4-triethylsilanyloxy-oct-7-en-2-one

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Chemical Property of (1S,3R,4S,5R)-5-(2-Benzyloxy-ethyl)-1-(tert-butyl-dimethyl-silanyloxy)-1-cyclohexyl-3,7-dimethyl-4-triethylsilanyloxy-oct-7-en-2-one

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Technology Process of (1S,3R,4S,5R)-5-(2-Benzyloxy-ethyl)-1-(tert-butyl-dimethyl-silanyloxy)-1-cyclohexyl-3,7-dimethyl-4-triethylsilanyloxy-oct-7-en-2-one

There total 6 articles about (1S,3R,4S,5R)-5-(2-Benzyloxy-ethyl)-1-(tert-butyl-dimethyl-silanyloxy)-1-cyclohexyl-3,7-dimethyl-4-triethylsilanyloxy-oct-7-en-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 79271-56-0
triethylsilyl trifluoromethyl sulfonate

: 83058-26-8
(1S,3R,4S,5R)-5-(2-Benzyloxy-ethyl)-1-(tert-butyl-dimethyl-silanyloxy)-1-cyclohexyl-4-hydroxy-3,7-dimethyl-oct-7-en-2-one

: 83005-61-2
(1S,3R,4S,5R)-5-(2-Benzyloxy-ethyl)-1-(tert-butyl-dimethyl-silanyloxy)-1-cyclohexyl-3,7-dimethyl-4-triethylsilanyloxy-oct-7-en-2-one

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; for 0.333333h; -10 deg C -> 0 deg C;
DOI:10.1021/ja00384a061

Reference yield:

: 10385-30-5
4-(benzyloxy)butanoic acid

: 83005-61-2
(1S,3R,4S,5R)-5-(2-Benzyloxy-ethyl)-1-(tert-butyl-dimethyl-silanyloxy)-1-cyclohexyl-3,7-dimethyl-4-triethylsilanyloxy-oct-7-en-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / lithium diisopropylamide, hexamethylphosphoramide / tetrahydrofuran; hexane / 1.5 h / 0 deg C -> room temperature

2: 98 percent / lithium aluminium hydride / tetrahydrofuran / 0.75 h / 0 deg C -> room temperature

3: 87 percent / CrO₃*2C₅H₅N / CH₂Cl₂ / 0.25 h / 0 °C

4: CH₂Cl₂ / 17 h / Ambient temperature

5: 100 percent / 2,6-lutidine / CH₂Cl₂ / 0.33 h / -10 deg C -> 0 deg C

With 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; dipyridine chromium trioxide; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja00384a061

Reference yield:

: 88155-25-3
C₂₄H₄₉BO₂Si

: 83005-61-2
(1S,3R,4S,5R)-5-(2-Benzyloxy-ethyl)-1-(tert-butyl-dimethyl-silanyloxy)-1-cyclohexyl-3,7-dimethyl-4-triethylsilanyloxy-oct-7-en-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂ / 17 h / Ambient temperature

2: 100 percent / 2,6-lutidine / CH₂Cl₂ / 0.33 h / -10 deg C -> 0 deg C

With 2,6-dimethylpyridine; In dichloromethane;
DOI:10.1021/ja00384a061