9-benzyl-2-(4-methylphenyl)-2,6-dihydro[1,2,4]triazolo-[4,3-c]quinazoline-3,5-dione

Base Information

Chemical Name:9-benzyl-2-(4-methylphenyl)-2,6-dihydro[1,2,4]triazolo-[4,3-c]quinazoline-3,5-dione
CAS No.:1189797-76-9
Molecular Formula:C₂₃H₁₈N₄O₂
Molecular Weight:382.422
Hs Code.:

Synonyms:9-benzyl-2-(4-methylphenyl)-2,6-dihydro[1,2,4]triazolo-[4,3-c]quinazoline-3,5-dione

Suppliers and Price of 9-benzyl-2-(4-methylphenyl)-2,6-dihydro[1,2,4]triazolo-[4,3-c]quinazoline-3,5-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 9-benzyl-2-(4-methylphenyl)-2,6-dihydro[1,2,4]triazolo-[4,3-c]quinazoline-3,5-dione

Chemical Property:

Purity/Quality:: 95%+ or 98%+ ^*data from raw suppliers

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Technology Process of 9-benzyl-2-(4-methylphenyl)-2,6-dihydro[1,2,4]triazolo-[4,3-c]quinazoline-3,5-dione

There total 14 articles about 9-benzyl-2-(4-methylphenyl)-2,6-dihydro[1,2,4]triazolo-[4,3-c]quinazoline-3,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1189797-63-4
9-bromo-2-(4-methylphenyl)-2,6-dihydro[1,2,4]triazolo-[4,3-c]quinazoline-3,5-dione

: 28493-54-1
benzyltributyltin

: 1189797-76-9
9-benzyl-2-(4-methylphenyl)-2,6-dihydro[1,2,4]triazolo-[4,3-c]quinazoline-3,5-dione

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; at 110 ℃; for 18h; Inert atmosphere; Sealed tube;
DOI:10.1016/j.bmc.2010.11.050

Reference yield:

: C₂₃H₁₇N₄O₂^(1-)*Na⁽¹⁺⁾

: 1189797-76-9
9-benzyl-2-(4-methylphenyl)-2,6-dihydro[1,2,4]triazolo-[4,3-c]quinazoline-3,5-dione

Guidance literature:: With acetic acid; at 110 - 124 ℃; for 1h;

Reference yield:

: 624-31-7
4-tolyl iodide

: 1189797-76-9
9-benzyl-2-(4-methylphenyl)-2,6-dihydro[1,2,4]triazolo-[4,3-c]quinazoline-3,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / copper(l) iodide; 1,10-Phenanthroline / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / 60 h / 110 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 20 °C

3.2: 0.5 h

4.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 18 h / 110 °C / Sealed tube; Inert atmosphere

With caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,10-Phenanthroline; In dichloromethane; N,N-dimethyl-formamide;