N-[2-(3,4-dimethoxyphenyl)ethyl]-3,3,3-trifluoro-2-hydroxy-2-phenylpropanamide

Base Information

Chemical Name:N-[2-(3,4-dimethoxyphenyl)ethyl]-3,3,3-trifluoro-2-hydroxy-2-phenylpropanamide
CAS No.:1414962-79-0
Molecular Formula:C₁₉H₂₀F₃NO₄
Molecular Weight:383.367
Hs Code.:

Synonyms:N-[2-(3,4-dimethoxyphenyl)ethyl]-3,3,3-trifluoro-2-hydroxy-2-phenylpropanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-(3,4-dimethoxyphenyl)ethyl]-3,3,3-trifluoro-2-hydroxy-2-phenylpropanamide

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Technology Process of N-[2-(3,4-dimethoxyphenyl)ethyl]-3,3,3-trifluoro-2-hydroxy-2-phenylpropanamide

There total 4 articles about N-[2-(3,4-dimethoxyphenyl)ethyl]-3,3,3-trifluoro-2-hydroxy-2-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₂₂F₃NO₅

: 1414962-79-0
N-[2-(3,4-dimethoxyphenyl)ethyl]-3,3,3-trifluoro-2-hydroxy-2-phenylpropanamide

Guidance literature:: With water; sodium hydroxide; In methanol; at 40 ℃; for 0.333333h; Microwave irradiation;
DOI:10.1021/co400111r

Reference yield:

: 434-45-7
2,2,2-Trifluoroacetophenone

: 49621-56-9
3-(3,4-dimethoxyphenyl)propanenitrile

: 64-19-7,77671-22-8
acetic acid

: 1414962-79-0
N-[2-(3,4-dimethoxyphenyl)ethyl]-3,3,3-trifluoro-2-hydroxy-2-phenylpropanamide

Guidance literature:: 2,2,2-Trifluoroacetophenone; 3-(3,4-dimethoxyphenyl)propanenitrile; acetic acid; at 40 ℃; for 0.333333h; Sonication;

With water; sodium hydroxide; In methanol; at 20 ℃; for 0.25h; Sonication;
DOI:10.1016/j.molstruc.2016.09.020

Reference yield:

: 14301-36-1
N-[2-(3,4-dimethoxyphenyl)ethyl]formamide

: 1414962-79-0
N-[2-(3,4-dimethoxyphenyl)ethyl]-3,3,3-trifluoro-2-hydroxy-2-phenylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; bis(trichloromethyl) carbonate / dichloromethane / 0.5 h / -10 °C

2: neat (no solvent) / 0.67 h / 40 °C / Microwave irradiation

3: sodium hydroxide; water / methanol / 0.33 h / 40 °C / Microwave irradiation

With bis(trichloromethyl) carbonate; water; triethylamine; sodium hydroxide; In methanol; dichloromethane; 2: |Passerini Condensation;
DOI:10.1021/co400111r