49621-56-9

Basic information

• Product Name: 3-(3,4-dimethoxyphenyl)propanenitrile
• Synonyms: 3-(3,4-Dimethoxyphenyl)propanenitrile; benzenepropanenitrile, 3,4-dimethoxy-
• CAS NO: 49621-56-9
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.2264
• Mol File: 49621-56-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 334.5°C at 760 mmHg
• Flash Point: 130°C
• Density: 1.061g/cm³
• Vapor Pressure: 0.000127mmHg at 25°C
• Refractive Index: 1.508
• CAS DataBase Reference: 3-(3,4-dimethoxyphenyl)propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-dimethoxyphenyl)propanenitrile(49621-56-9)
• EPA Substance Registry System: 3-(3,4-dimethoxyphenyl)propanenitrile(49621-56-9)

Safety Data

• Hazardous Substances Data: 49621-56-9(Hazardous Substances Data)

Usage

General Description

3-(3,4-Dimethoxyphenyl)propanenitrile, also known as DMPN, is a chemical compound with the molecular formula C11H13NO2. It is a nitrile derivative of 3,4-dimethoxyphenylpropanol and is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. DMPN is a colorless to light yellow liquid with a slightly sweet odor. It is soluble in most organic solvents and exhibits moderate toxicity, with potential adverse effects on the respiratory and central nervous systems. DMPN is primarily used as a building block in the production of new chemical entities and drug discovery research.

Upstream product

• 27160-08-3 2-(3,4-dimethoxyphenyl)-ethylchloride 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 86213-20-9 2-cyano-3-(3,4-dimethoxyphenyl)acrylic acid 
• 55502-61-9 2-cyano-3-(3,4-dimethoxyphenyl)propionic acid 
• 64728-23-0 2-(3,4-dimethoxyphenyl)-1-iodoethane 
• 151-50-8 potassium cyanide 
• 14773-41-2 3-(3,4-dimethoxyphenyl)propionic acid amide 
• 2537-48-6 diethyl 1-cyanomethylphosphonate 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 773837-37-9 sodium cyanide 
• 75803-23-5 methanesulphonic acid,2-(3,4-dimethoxyphenyl)ethyl ester 
• 2859-78-1 4-Bromoveratrole 
• 37629-85-9 (2E)-3-(3,4-dimethoxyphenyl)prop-2-enenitrile 
• 7417-21-2 2-(3,4-dimethoxyphenyl)ethyl alcohol 

Downstream Products

• 79623-34-0 3-(3,4-dimethoxy-5-hydroxyphenyl)propionitrile 
• 79623-33-9 2,2'-bis(2-cyanoethyl)-4,4',5,5'-tetramethoxybiphenyl 
• 94385-84-9 3-(3,4-dimethoxy-phenyl)-1-(4-hydroxy-2,6-dimethoxy-phenyl)-propan-1-one 
• 35249-62-8 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile 
• 1414962-79-0 N-[2-(3,4-dimethoxyphenyl)ethyl]-3,3,3-trifluoro-2-hydroxy-2-phenylpropanamide 
• 155974-00-8 ivabradine 
• 1086026-31-4 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-(methyl)amino]propyl}-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 
• 148870-56-8 ({3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl)(methyl)amine 
• 35202-55-2 1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine hydrochloride 
• 35202-54-1 3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile 
• 1015239-71-0 N-(3-(3,4-dimethoxyphenyl)-1-methoxypropyl) isobutyramide 
• 299442-02-7 5-[2-(3,4-dimethoxy-phenyl)-ethyl]-[1,3,4]thiadiazol-2-ylamine 
• 52679-49-9 3-(2'-bromo-4',5'-dimethoxyphenyl)propionic acid 

Relevant articles and documents

Electrochemical Tandem Olefination and Hydrogenation Reaction with Ammonia

An electrochemical Horner-Wadsworth-Emmons/hydrogenation tandem reaction was achieved using ammonia as electron and proton donors. The reaction could give two-carbon-elongated ester and nitrile from aldehyde or ketones directly. This reaction could proceed with a catalytic amount of base or even without a base. The ammonia provides both the electron and proton for this tandem reaction and enables the catalyst-free hydrogenation of an α,β-unsaturated HWE intermediate. More than 40 examples were reported, and functional groups, including heterocycles and hydroxyl, were tolerated.

Investigation of dopamine analogues: Synthesis, mechanistic understanding, and structure-property relationship

Dopamine, perhaps the simplest molecule that covalently links catechol and amine, together with its derivatives, has shown impressive adhesive and coating properties with its polymers. However, the scope of the molecules is rather limited, and the polymer

PROCESS FOR THE SYNTHESIS OF 3-(2-BROMO-4,5-DIMETHOXYPHENYL)PROPANENITRILE, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID

Process for the synthesis of the compound of formula (I): Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.