(R)-N-((R)-3-allyl-1-(4-methoxybenzyl)-2-oxoindolin-3-yl)-2-methylpropane-2-sulfinamide

Base Information

• Chemical Name: (R)-N-((R)-3-allyl-1-(4-methoxybenzyl)-2-oxoindolin-3-yl)-2-methylpropane-2-sulfinamide
• CAS No.: 1160028-22-7
• Molecular Formula: C₂₃H₂₈N₂O₃S
• Molecular Weight: 412.553
• Mol file: 1160028-22-7.mol

Synonyms:(R)-N-((R)-3-allyl-1-(4-methoxybenzyl)-2-oxoindolin-3-yl)-2-methylpropane-2-sulfinamide

Chemical Property of (R)-N-((R)-3-allyl-1-(4-methoxybenzyl)-2-oxoindolin-3-yl)-2-methylpropane-2-sulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-((R)-3-allyl-1-(4-methoxybenzyl)-2-oxoindolin-3-yl)-2-methylpropane-2-sulfinamide

There total 1 articles about (R)-N-((R)-3-allyl-1-(4-methoxybenzyl)-2-oxoindolin-3-yl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

(R)-N-(1-(4-methoxybenzyl)-2-oxoindolin-3-ylidene)-2-methylpropane-2-sulfinamide (1160027-97-3) + allylmagnesium bromide (1730-25-2) → (R)-N-((S)-3-allyl-1-(4-methoxybenzyl)-2-oxoindolin-3-yl)-2-methylpropane-2-sulfinamide (1422181-74-5) + (R)-N-((R)-3-allyl-1-(4-methoxybenzyl)-2-oxoindolin-3-yl)-2-methylpropane-2-sulfinamide (1160028-22-7)

Guidance literature:

(R)-N-(1-(4-methoxybenzyl)-2-oxoindolin-3-ylidene)-2-methylpropane-2-sulfinamide; With magnesium bromide; In dichloromethane; at -40 - 20 ℃; for 13h; Inert atmosphere;

allylmagnesium bromide; In dichloromethane; at -40 - 20 ℃; Inert atmosphere;

With water; ammonium chloride; In dichloromethane; optical yield given as %de; Inert atmosphere;

DOI:10.1021/jo900623c

Reference yield: 75.0%

(R)-N-((R)-3-allyl-1-(4-methoxybenzyl)-2-oxoindolin-3-yl)-2-methylpropane-2-sulfinamide (1160028-22-7) → (R)-3-allyl-3-amino-1-(4-methoxybenzyl)indolin-2-one (1160028-30-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/jo900623c

upstream raw materials:

(R)-N-(1-(4-methoxybenzyl)-2-oxoindolin-3-ylidene)-2-methylpropane-2-sulfinamide

allylmagnesium bromide

Downstream raw materials:

(R)-3-allyl-3-amino-1-(4-methoxybenzyl)indolin-2-one