methyl 1,6-dihydro-1-(4-methylbenzyl)-6-oxo-2-pyrazinecarboxylate 4-oxide

Base Information

• Chemical Name: methyl 1,6-dihydro-1-(4-methylbenzyl)-6-oxo-2-pyrazinecarboxylate 4-oxide
• CAS No.: 77775-44-1
• Molecular Formula: C₁₄H₁₄N₂O₄
• Molecular Weight: 274.276
• Mol file: 77775-44-1.mol

Synonyms:methyl 1,6-dihydro-1-(4-methylbenzyl)-6-oxo-2-pyrazinecarboxylate 4-oxide

Chemical Property of methyl 1,6-dihydro-1-(4-methylbenzyl)-6-oxo-2-pyrazinecarboxylate 4-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 1,6-dihydro-1-(4-methylbenzyl)-6-oxo-2-pyrazinecarboxylate 4-oxide

There total 5 articles about methyl 1,6-dihydro-1-(4-methylbenzyl)-6-oxo-2-pyrazinecarboxylate 4-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

4-Methylbenzyl bromide (104-81-4) + methyl 1,6-dihydro-6-oxo-2-pyrazinecarboxylate 4-oxide (36341-35-2) → methyl 6-(4-methylbenzyloxy)-2-pyrazinecarboxylate 4-oxide (77775-45-2) + methyl 1,6-dihydro-1-(4-methylbenzyl)-6-oxo-2-pyrazinecarboxylate 4-oxide (77775-44-1)

Guidance literature:

With lithium carbonate; In N,N-dimethyl acetamide; for 10h; Ambient temperature;

DOI:10.1248/cpb.29.88

Reference yield:

methyl 6-chloro-2-pyrazinecarboxylate 4-oxide (77775-33-8) → methyl 1,6-dihydro-1-(4-methylbenzyl)-6-oxo-2-pyrazinecarboxylate 4-oxide (77775-44-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) aq. NaOH; 2.) MeOH / 1.) 75 deg C, 5 h; 2.) reflux, 30 min

2: 56 percent / HCl gas / Ambient temperature

3: 9 percent / Li₂CO₃ / N,N-dimethyl-acetamide / 10 h / Ambient temperature

With hydrogenchloride; methanol; sodium hydroxide; lithium carbonate; In N,N-dimethyl acetamide;

DOI:10.1248/cpb.29.88

Reference yield:

6-hydroxymethyl-2(1H)-pyrazinone 4-oxide (72788-96-6) → methyl 1,6-dihydro-1-(4-methylbenzyl)-6-oxo-2-pyrazinecarboxylate 4-oxide (77775-44-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 40 percent / nickel peroxide / aq. NaOH / 4 h / Ambient temperature

2: 56 percent / HCl gas / Ambient temperature

3: 9 percent / Li₂CO₃ / N,N-dimethyl-acetamide / 10 h / Ambient temperature

With hydrogenchloride; nickel(IV) oxide; lithium carbonate; In sodium hydroxide; N,N-dimethyl acetamide;

DOI:10.1248/cpb.29.88

upstream raw materials:

4-Methylbenzyl bromide

methyl 1,6-dihydro-6-oxo-2-pyrazinecarboxylate 4-oxide

methyl 6-chloro-2-pyrazinecarboxylate 4-oxide

6-hydroxymethyl-2(1H)-pyrazinone 4-oxide

Downstream raw materials:

1,6-dihydro-1-(4-methylbenzyl)-6-oxo-2-pyrazinecarboxylic acid 4-oxide