1,6-dihydro-1-(4-methylbenzyl)-6-oxo-2-pyrazinecarboxylic acid 4-oxide

Base Information

• Chemical Name: 1,6-dihydro-1-(4-methylbenzyl)-6-oxo-2-pyrazinecarboxylic acid 4-oxide
• CAS No.: 77775-46-3
• Molecular Formula: C₁₃H₁₂N₂O₄
• Molecular Weight: 260.249
• Mol file: 77775-46-3.mol

Synonyms:1,6-dihydro-1-(4-methylbenzyl)-6-oxo-2-pyrazinecarboxylic acid 4-oxide

Chemical Property of 1,6-dihydro-1-(4-methylbenzyl)-6-oxo-2-pyrazinecarboxylic acid 4-oxide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1,6-dihydro-1-(4-methylbenzyl)-6-oxo-2-pyrazinecarboxylic acid 4-oxide

There total 7 articles about 1,6-dihydro-1-(4-methylbenzyl)-6-oxo-2-pyrazinecarboxylic acid 4-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

methyl 1,6-dihydro-1-(4-methylbenzyl)-6-oxo-2-pyrazinecarboxylate 4-oxide (77775-44-1) → 1,6-dihydro-1-(4-methylbenzyl)-6-oxo-2-pyrazinecarboxylic acid 4-oxide (77775-46-3)

Guidance literature:

With potassium carbonate; In methanol; at 50 ℃; for 3h;

DOI:10.1248/cpb.29.88

Reference yield:

4-Methylbenzyl bromide (104-81-4) → 1,6-dihydro-1-(4-methylbenzyl)-6-oxo-2-pyrazinecarboxylic acid 4-oxide (77775-46-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 9 percent / Li₂CO₃ / N,N-dimethyl-acetamide / 10 h / Ambient temperature

2: 61 percent / 0.2N aq. K₂CO₃ / methanol / 3 h / 50 °C

With lithium carbonate; potassium carbonate; In methanol; N,N-dimethyl acetamide;

DOI:10.1248/cpb.29.88

Reference yield:

methyl 6-chloro-2-pyrazinecarboxylate 4-oxide (77775-33-8) → 1,6-dihydro-1-(4-methylbenzyl)-6-oxo-2-pyrazinecarboxylic acid 4-oxide (77775-46-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) aq. NaOH; 2.) MeOH / 1.) 75 deg C, 5 h; 2.) reflux, 30 min

2: 56 percent / HCl gas / Ambient temperature

3: 9 percent / Li₂CO₃ / N,N-dimethyl-acetamide / 10 h / Ambient temperature

4: 61 percent / 0.2N aq. K₂CO₃ / methanol / 3 h / 50 °C

With hydrogenchloride; methanol; sodium hydroxide; lithium carbonate; potassium carbonate; In methanol; N,N-dimethyl acetamide;

DOI:10.1248/cpb.29.88

upstream raw materials:

methyl 1,6-dihydro-1-(4-methylbenzyl)-6-oxo-2-pyrazinecarboxylate 4-oxide

4-Methylbenzyl bromide

methyl 6-chloro-2-pyrazinecarboxylate 4-oxide

6-hydroxymethyl-2(1H)-pyrazinone 4-oxide