methyl 3-[3-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoate

Base Information

Chemical Name:methyl 3-[3-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoate
CAS No.:130475-75-1
Molecular Formula:C₂₅H₃₂N₄O₅S
Molecular Weight:500.619
Hs Code.:

Synonyms:methyl 3-[3-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoate

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Chemical Property of methyl 3-[3-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoate

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Technology Process of methyl 3-[3-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoate

There total 11 articles about methyl 3-[3-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 130475-74-0
3-<4-<4-(2-methoxyphenyl)piperazin-1-yl>butyl>thieno<3,4-d>pyrimidine-2,4-dione

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 130475-75-1
methyl 3-[3-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoate

Guidance literature:: With N-benzyl-trimethylammonium hydroxide; In methanol; chloroform; Heating;

Reference yield:

: 69363-85-5
methyl 4-aminothiophene-3-carboxylate

: 130475-75-1
methyl 3-[3-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent / toluene / 16 h / Ambient temperature

2: NaI, Na₂CO₃ / propan-2-ol / 16 h / Heating

3: aq percent50 NaOH / methanol / 0.75 h / Heating

4: 59 percent / aq. C₆H₅CH₂N(CH₃)3OH / CHCl₃; methanol / Heating

With sodium hydroxide; N-benzyl-trimethylammonium hydroxide; sodium carbonate; sodium iodide; In methanol; chloroform; isopropyl alcohol; toluene;

Reference yield:

: 35386-24-4
1-(2-Methoxyphenyl)piperazine

: 130475-75-1
methyl 3-[3-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / acetonitrile / Heating

2: NH₂NH₂ / ethanol / Heating

3: 1.) AlMe₃ / 1.) toluene, 10 min,ice-cold, 2.) 8 h, reflux

4: 59 percent / aq. C₆H₅CH₂N(CH₃)3OH / CHCl₃; methanol / Heating

With trimethylaluminum; N-benzyl-trimethylammonium hydroxide; potassium carbonate; hydrazine; In methanol; ethanol; chloroform; acetonitrile;