3-[3-[4-[4-(2-methoxyphenyl]piperazin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoic acid

Base Information

Chemical Name:3-[3-[4-[4-(2-methoxyphenyl]piperazin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoic acid
CAS No.:130475-76-2
Molecular Formula:C₂₄H₃₀N₄O₅S
Molecular Weight:486.592
Hs Code.:

Synonyms:3-[3-[4-[4-(2-methoxyphenyl]piperazin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoic acid

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Chemical Property of 3-[3-[4-[4-(2-methoxyphenyl]piperazin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoic acid

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Technology Process of 3-[3-[4-[4-(2-methoxyphenyl]piperazin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoic acid

There total 12 articles about 3-[3-[4-[4-(2-methoxyphenyl]piperazin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 130475-75-1
methyl 3-[3-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoate

: 130475-76-2
3-[3-[4-[4-(2-methoxyphenyl]piperazin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoic acid

Guidance literature:: With sodium hydroxide; In methanol; Heating;

Reference yield:

: 69363-85-5
methyl 4-aminothiophene-3-carboxylate

: 130475-76-2
3-[3-[4-[4-(2-methoxyphenyl]piperazin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / toluene / 16 h / Ambient temperature

2: NaI, Na₂CO₃ / propan-2-ol / 16 h / Heating

3: aq percent50 NaOH / methanol / 0.75 h / Heating

4: 59 percent / aq. C₆H₅CH₂N(CH₃)3OH / CHCl₃; methanol / Heating

5: 96 percent / 50percent aq. NaOH / methanol / Heating

With sodium hydroxide; N-benzyl-trimethylammonium hydroxide; sodium carbonate; sodium iodide; In methanol; chloroform; isopropyl alcohol; toluene;

Reference yield:

: 35386-24-4
1-(2-Methoxyphenyl)piperazine

: 130475-76-2
3-[3-[4-[4-(2-methoxyphenyl]piperazin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / acetonitrile / Heating

2: NH₂NH₂ / ethanol / Heating

3: 1.) AlMe₃ / 1.) toluene, 10 min,ice-cold, 2.) 8 h, reflux

4: 59 percent / aq. C₆H₅CH₂N(CH₃)3OH / CHCl₃; methanol / Heating

5: 96 percent / 50percent aq. NaOH / methanol / Heating

With sodium hydroxide; trimethylaluminum; N-benzyl-trimethylammonium hydroxide; potassium carbonate; hydrazine; In methanol; ethanol; chloroform; acetonitrile;