methyl {(2S,4R)-2-[4-(trifluoromethyl)phenyl]-1-[4,4,4-trifluoro-1-(3,3,3-trifluoropropyl)butyl]piperidin-4-yl}acetate

Base Information

Chemical Name:methyl {(2S,4R)-2-[4-(trifluoromethyl)phenyl]-1-[4,4,4-trifluoro-1-(3,3,3-trifluoropropyl)butyl]piperidin-4-yl}acetate
CAS No.:956466-17-4
Molecular Formula:C₂₂H₂₆F₉NO₂
Molecular Weight:507.44
Hs Code.:

Synonyms:methyl {(2S,4R)-2-[4-(trifluoromethyl)phenyl]-1-[4,4,4-trifluoro-1-(3,3,3-trifluoropropyl)butyl]piperidin-4-yl}acetate

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Chemical Property of methyl {(2S,4R)-2-[4-(trifluoromethyl)phenyl]-1-[4,4,4-trifluoro-1-(3,3,3-trifluoropropyl)butyl]piperidin-4-yl}acetate

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Technology Process of methyl {(2S,4R)-2-[4-(trifluoromethyl)phenyl]-1-[4,4,4-trifluoro-1-(3,3,3-trifluoropropyl)butyl]piperidin-4-yl}acetate

There total 4 articles about methyl {(2S,4R)-2-[4-(trifluoromethyl)phenyl]-1-[4,4,4-trifluoro-1-(3,3,3-trifluoropropyl)butyl]piperidin-4-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 884602-78-2
(+)-methyl {(2S,4R)-2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetate

: 332-86-5
1,1,1,7,7,7-hexafluoro-heptan-4-one

: 956466-17-4
methyl {(2S,4R)-2-[4-(trifluoromethyl)phenyl]-1-[4,4,4-trifluoro-1-(3,3,3-trifluoropropyl)butyl]piperidin-4-yl}acetate

Guidance literature:: (+)-methyl {(2S,4R)-2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetate; 1,1,1,7,7,7-hexafluoro-heptan-4-one; With titanium tetrachloride; triethylamine; In dichloromethane; at -78 - 0 ℃; for 0.0833333h;

With sodium cyanoborohydride; In methanol; dichloromethane; at -78 - 20 ℃;

With water; In methanol; dichloromethane; ethyl acetate;

Reference yield:

: 884600-79-7
methyl {2-[4-(trifluoromethyl)phenyl]-4-pyridinyl}acetate

: 956466-17-4
methyl {(2S,4R)-2-[4-(trifluoromethyl)phenyl]-1-[4,4,4-trifluoro-1-(3,3,3-trifluoropropyl)butyl]piperidin-4-yl}acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol / 5 h / 1034.32 Torr

2.1: water; sodium hydrogencarbonate

3.1: isopropyl alcohol / 20 °C

3.2: 2 h

4.1: water; sodium carbonate

5.1: titanium tetrachloride; triethylamine / dichloromethane / 0.08 h / -78 - 0 °C

5.2: -78 - 20 °C

With hydrogenchloride; water; hydrogen; titanium tetrachloride; sodium hydrogencarbonate; sodium carbonate; triethylamine; platinum(IV) oxide; In methanol; dichloromethane; isopropyl alcohol;

Reference yield:

: (+/-)-cis-methyl {2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate hydrochloride

: 956466-17-4
methyl {(2S,4R)-2-[4-(trifluoromethyl)phenyl]-1-[4,4,4-trifluoro-1-(3,3,3-trifluoropropyl)butyl]piperidin-4-yl}acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; sodium hydrogencarbonate

2.1: isopropyl alcohol / 20 °C

2.2: 2 h

3.1: water; sodium carbonate

4.1: titanium tetrachloride; triethylamine / dichloromethane / 0.08 h / -78 - 0 °C

4.2: -78 - 20 °C

With water; titanium tetrachloride; sodium hydrogencarbonate; sodium carbonate; triethylamine; In dichloromethane; isopropyl alcohol;