884600-79-7

Upstream product

• 452342-99-3 4-methyl-2-[4-(trifluoromethyl)phenyl]pyridine 
• 616-38-6 carbonic acid dimethyl ester 

Downstream Products

• 1038996-09-6 methyl 2-methyl-2-{2-[4-(trifluoromethyl)phenyl]pyridin-4-yl}propanoate 
• 884601-89-2 (+/-)-methyl 1-{2-[4-(trifluoromethyl)phenyl]pyridin-4-yl}cyclopent-3-ene-1-carhoxylate 
• 956466-05-0 methyl {(2S,4R)-1-[(1S)-4-methyl-1-(4,4,4-trifluorobutyl)pent-4-en-2-yn-1-yl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate 
• 956466-17-4 methyl {(2S,4R)-2-[4-(trifluoromethyl)phenyl]-1-[4,4,4-trifluoro-1-(3,3,3-trifluoropropyl)butyl]piperidin-4-yl}acetate 
• 956466-07-2 {(2S,4R)-1-{(1R)-1-[(benzyloxy)methyl]-4-methylpent-4-en-2-yn-1-yl}-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetic acid methyl ester 
• 956466-06-1 methyl {(2S,4R)-1-[(1S)-5,5,5-trifluoro-1-(3-methylbutyl)pentyl]-2-[4-(trifluoromethyl)phenyl] piperidin-4-yl}acetate 
• 956466-22-1 C₂₄H₃₁F₆NO₂ 
• 956466-21-0 C₂₄H₂₇F₆NO₂ 
• 956466-09-4 methyl {(2S,4R)-1-[(1R)-1-(hydroxymethyl)-4-methylpentyl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate 
• 956466-18-5 methyl {(2S,4R)-1-[(1S)-1-(3,3-dimethylbutyl)-4,4-dimethylpent-2-yn-1-yl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate 
• 956466-02-7 methyl {(2S,4R)-1-[(1S)-4-methyl-1-(3-methylbutyl)pent-4-en-2-yn-1-yl]-2-[4-(trifluoromethyl)phenyl]-piperidin-4-yl}-acetate 
• 956466-11-8 {(2S,4R)-1-[(1R)-1-((difluoromethoxy)methyl)-4-methylpentyl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetic acid methyl ester 
• 956466-04-9 methyl {(2S,4R)-1-[(1S,2Z)-4-methyl-1-(3-methylbutyl)pent-2-en-1-yl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate 
• 956466-03-8 methyl {(2S,4R)-1-[4-methyl-1-(3-methylbutyl)pentyl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate 

Relevant academic research and scientific papers

Piperidine-derived γ-secretase modulators

This Letter details the SAR of a novel series of piperidine-derived γ-secretase modulators. Compound 10h was found to be a potent modulator in vitro, which on further profiling, was found to decrease Aβ42, increase Aβ38 and have no effect on Aβ40 levels.

Fluorinated piperidine acetic acids as γ-secretase modulators

We report herein a novel series of difluoropiperidine acetic acids as modulators of γ-secretase. Synthesis of 2-aryl-3,3-difluoropiperidine analogs was facilitated by a unique and selective β-difluorination with Selectfluor. Compounds 1f and 2c were selec

PIPERIDINES AND RELATED COMPOUNDS FOR THE TREATMENT OF DEMENTIA

Compounds of formula I: modulate the action of gamma secretase, and hence find use in treatment of Alzheimer's disease and related conditions.

SILYLATED PIPERIDINE DERIVATIVES

Compounds of formula I: I wherein at least one of R4 and R5 comprises Si(R6)3 as a substituent selectively attenuate production of A?(1-42) and hence find use in treatment of Alzheimer's disease and related conditions.

PIPERIDINE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE

Compounds of formula (I) modulate the activity of gamma secretase and hence find use in treatment or prevention of Alzheimer's disease and related conditions.

PIPERIDINES AND RELATED COMPOUNDS FOR THE TREATMENT OF DEMENTIA

Compounds of formula I: modulate the action of gamma secretase, and hence find use in treatment of Alzheimer's disease and related conditions.

PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER’S DISEASE

Compounds of formula (I) are modulators of gamma-secretase, and hence are useful in treatment of Alzheimer’s disease.

PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE

Compounds of formula (I), selectively inhibit production of Aβ (1-42) and hence are useful in treatment or prevention of disease assocaited with deposition of β -amyloid in the brain.