(S)-5-[(3,5-bis-trifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid

Base Information

Chemical Name:(S)-5-[(3,5-bis-trifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid
CAS No.:938464-76-7
Molecular Formula:C₃₄H₃₄F₆N₂O₆
Molecular Weight:680.644
Hs Code.:

Synonyms:(S)-5-[(3,5-bis-trifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid

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Chemical Property of (S)-5-[(3,5-bis-trifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid

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Technology Process of (S)-5-[(3,5-bis-trifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid

There total 4 articles about (S)-5-[(3,5-bis-trifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: (S)-5-(3,5-bis-trifluoromethylbenzylamino)-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid trifluoroacetate

: 24424-99-5
di-tert-butyl dicarbonate

: 938464-76-7
(S)-5-[(3,5-bis-trifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/ja069128s

Reference yield: 98.0%

: 938464-88-1
(S)-4-[(3,5-bis-trifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

: (S)-5-(3,5-Bis-trifluoromethyl-benzylamino)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanoic acid trifluoroacetate

: 938464-76-7
(S)-5-[(3,5-bis-trifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid

Guidance literature:: In dichloromethane;

Reference yield:

: Nα-(9-Fluorenylmethoxycarbonyl)-L-ornithine Trifluoroacetate Salt

: 938464-76-7
(S)-5-[(3,5-bis-trifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / sodium triacetoxyborohydride; trifluoroacetic acid / dimethylformamide / 1 h / 20 °C

2: 98 percent / aq. NaHCO₃ / CH₂Cl₂ / 3 h / 20 °C

With sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja069128s