(S)-4-[(3,5-bis-trifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

Base Information

Chemical Name:(S)-4-[(3,5-bis-trifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid
CAS No.:938464-88-1
Molecular Formula:C₃₃H₃₂F₆N₂O₆
Molecular Weight:666.617
Hs Code.:

Synonyms:(S)-4-[(3,5-bis-trifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

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Chemical Property of (S)-4-[(3,5-bis-trifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

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Technology Process of (S)-4-[(3,5-bis-trifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

There total 4 articles about (S)-4-[(3,5-bis-trifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: (S)-4-(3,5-bis-trifluoromethylbenzylamino)-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid trifluoroacetate

: 24424-99-5
di-tert-butyl dicarbonate

: 938464-88-1
(S)-4-[(3,5-bis-trifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

Guidance literature:: With sodium hydrogencarbonate; In ethyl acetate; at 20 ℃; for 3h;
DOI:10.1021/ja069128s

Reference yield: 83.0%

: 938464-88-1
(S)-4-[(3,5-bis-trifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

Guidance literature:

Reference yield:

: C₁₉H₂₀N₂O₄*CF₃CO₂H

: 938464-88-1
(S)-4-[(3,5-bis-trifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / sodium triacetoxyborohydride; trifluoroacetic acid / dimethylformamide / 1 h / 20 °C

2: 83 percent / aq. NaHCO₃ / ethyl acetate / 3 h / 20 °C

With sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; trifluoroacetic acid; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja069128s